Fluvastatin

Fluvastatin

Systematic (IUPAC) name
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Clinical data
Trade names	Lescol
AHFS/Drugs.com	monograph
MedlinePlus	a694010
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Protein binding	98%
Half-life	2.5 hours
Identifiers
CAS number	93957-54-1^Y
ATC code	C10AA04
PubChem	CID 446155
DrugBank	APRD00346
ChemSpider	393587^Y
UNII	4L066368AS^Y
KEGG	D07983^Y
ChEBI	CHEBI:38565^Y
ChEMBL	CHEMBL1078^Y
Chemical data
Formula	C₂₄H₂₆F N O₄
Mol. mass	411.466 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1^Y Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N^Y
N(what is this?) (verify)

Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It has also been shown to exhibit antiviral activity against Hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.^[1]

References

^ Bader T, Fazili J, Madhoun M, et al. (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol. 103 (6): 1383. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471.

Lipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe • SCH-48461

Bile acid sequestrants/resins (LDL)	Cholestyramine • Colestipol • Colestilan • Colextran • Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)	Simvastatin^# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin^‡

Niacin and derivatives (HDL and LDL)	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox

Blood vessels

Fibrates (PPAR)	Clofibrate^‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride • Clinofibrate

CETP inhibitors (HDL)	Anacetrapib^† • Dalcetrapib • Evacetrapib • Torcetrapib^§

Combinations

Niacin/lovastatin • Niacin/simvastatin • Ezetimibe/simvastatin • Niacin/laropiprant

Other

Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat^§ • Mipomersen • Alipogene tiparvovec

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)