Lercanidipine

Lercanidipine
Systematic (IUPAC) name
2[(3,3-diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 100427-26-7
ATC code C08CA13
PubChem CID 65866
DrugBank APRD00193
ChemSpider 59276 Y
UNII V7XTJ4R0BH Y
KEGG D08111 Y
ChEMBL CHEMBL250270 Y
Chemical data
Formula C36H41N3O6 
Mol. mass 611.727 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Lercanidipine is a calcium channel blocker of the dihydropyridine class.It is sold under various commercial names including Zanidip,which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.[1]

References

  1. ^ Int J Clin Pract. 2006 November Full text at PMC: 1636683

Further reading

  • Lin T, Voon W, Yen H, Huang C, Su H, Lai W, Sheu S (2006). "Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters.". Kaohsiung J Med Sci 22 (4): 177–83. doi:10.1016/S1607-551X(09)70304-3. PMID 16679299. 
  • Martinez M, Lopes L, Coelho E, Nobre F, Rocha J, Gerlach R, Tanus-Santos J (2006). "Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension.". J Cardiovasc Pharmacol 47 (1): 117–22. doi:10.1097/01.fjc.0000196241.96759.71. PMID 16424795. 
  • Agrawal R, Marx A, Haller H (2006). "Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension.". J Hypertens 24 (1): 185–92. doi:10.1097/01.hjh.0000198987.34588.11. PMID 16331117. 

External links

Selective
Dihydropyridines ("-dipine")
1-4 Benzothiazepines ("-tiazem")
Non-selective
Other/ungrouped

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)