Lenvatinib

Lenvatinib
Systematic (IUPAC) name
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide
Clinical data
Pregnancy cat.  ?
Legal status Investigational
Identifiers
CAS number 417716-92-8 Y
ATC code None
PubChem CID 9823820
UNII EE083865G2 Y
ChEBI CHEBI:816009
ChEMBL CHEMBL1289601
Chemical data
Formula C21H19ClN4O4 
Mol. mass 426.853 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Lenvatinib (E7080) is a multi-kinase inhibitor that is being investigated for the treatment of various types of cancer by Eisai Co. It inhibits both VEGFR2 and VEGFR3 kinases.[1]

Clinical trials

Lenvatinib has had promising results from a phase I clinical trial in 2006[2] and is being tested in several phase II trials as of October 2011, for example against hepatocellular carcinoma.[3] After a phase II trial testing the treatment of thyroid cancer has been completed with modestly encouraging results,[4] the manufacturer launched a phase III trial in March 2011.[5]

References

  1. ^ Matsui, J.; Funahashi, Y.; Uenaka, T.; Watanabe, T.; Tsuruoka, A.; Asada, M. (2008). "Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase". Clinical Cancer Research 14 (17): 5459–65. doi:10.1158/1078-0432.CCR-07-5270. PMID 18765537. 
  2. ^ Glen, H; D. Boss, T. R. Evans, M. Roelvink, J. M. Saro, P. Bezodis, W. Copalu, A. Das, G. Crosswell, J. H. Schellens (2007). "A phase I dose finding study of E7080 in patients (pts) with advanced malignancies". Journal of Clinical Oncology, ASCO Annual Meeting Proceedings Part I 25 (18S): 14073. http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=47&abstractID=32665. 
  3. ^ ClinicalTrials.gov NCT00946153 Study of E7080 in Patients With Advanced Hepatocellular Carcinoma (HCC)
  4. ^ Gild, M. L.; Bullock, M.; Robinson, B. G.; Clifton-Bligh, R. (2011). "Multikinase inhibitors: A new option for the treatment of thyroid cancer". Nature Reviews Endocrinology 7 (10): 617–624. doi:10.1038/nrendo.2011.141. PMID 21862995.  edit
  5. ^ ClinicalTrials.gov NCT01321554 A Trial of E7080 in 131I-Refractory Differentiated Thyroid Cancer