Loxtidine

Loxtidine
Systematic (IUPAC) name
[1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
Clinical data
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 76956-02-0
ATC code None
PubChem CID 55473
ChemSpider 50093
UNII X16K5179V5
Chemical data
Formula C19H29N5O2 
Mol. mass 359.47 g/mol
SMILES eMolecules & PubChem

Loxtidine (INN), also known as lavoltidine (USAN, BAN) or AH-23,844, is a highly potent and selective H2 receptor antagonist which was under development as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.[1][2]

Synthesis

[3]

See also

References

  1. ^ Washington, Neena (1991). Antacids and anti-reflux agents. Boca Raton: CRC Press. ISBN 0-8493-5444-7. http://books.google.com/books?id=MKxtXgtt5SIC&lpg=PA250&dq=loxtidine&pg=PA250#v=onepage&q&f=false. 
  2. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. http://books.google.com/books?id=x2Su3GKCvtsC&lpg=PA4087&dq=lavoltidine&pg=PA4087#v=onepage&q&f=false. 
  3. ^ Clitherow, J. W.; Bradshaw, J.; Price, B. J.; Martin-Smith, M.; Mackinon, J. W. M.; Judd, D. B.; Hayes, R.; Carey, L.; 1983, EP 0016565 .
Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD (A02B)
H2 antagonists ("-tidine")
Cimetidine • Famotidine • Lafutidine • Loxtidine • Niperotidine • Nizatidine • Ranitidine • Roxatidine
Prostaglandins (E)/analogues ("-prost-")
Proton-pump inhibitors ("-prazole")
Other

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte