Laudexium metilsulfate

Laudexium metilsulfate
Systematic (IUPAC) name
1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium methyl sulfate
Clinical data
Pregnancy cat.  ?
Legal status discontinued from clinical use
Routes IV
Pharmacokinetic data
Bioavailability 100% (IV)
Identifiers
CAS number 3253-60-9 Y
ATC code  ?
PubChem CID 18618
UNII D067KDG4NU N
Synonyms Laudolissin
Chemical data
Formula C54H80N2O16S2 
Mol. mass 1077.35 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Laudexium[1] is no longer used in clinical practice, though it was introduced clinically in the early 1950s. It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine.[2] Because of its non-depolarizing mechanism of action, its pharmacological action could be antagonized by anticholinesterases. However, it was the reports of significant post-operative re-curarization[3] which essentially ensured the displacement of laudexium from clinical use.

References

  1. ^ Taylor EP (1952). "Synthetic neuromuscular blocking agents. Part II. Bis(quaternary ammonium salts) derived from laudanosine". J Chem Soc: 142–145. doi:10.1039/JR9520000142. 
  2. ^ Hunter AR (1955). "The action of laudexium in man and experimental animals". Br J Anaesth 27 (2): 73–79. doi:10.1093/bja/27.2.73. PMID 13230365. 
  3. ^ Collier HO, Macauley B (1952). "The pharmacological properties of "laudolissin" a long-acting curarizing agent". Br J Pharmacol Chemother 7 (3): 398–408. PMC 1509112. PMID 12978243. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1509112. 

External links

Peripherally acting
(primarily antinicotinic,
NMJ block)

ultra-short duration: Gantacurium

short duration: Mivacurium  • Chandonium

intermediate duration: Atracurium  • Cisatracurium  • Fazadinium  • Rocuronium  • Vecuronium

long duration: Doxacurium • Dimethyltubocurarine • Pancuronium • Pipecuronium  • Laudexium  • Gallamine

unsorted: Hexafluronium (Hexafluorenium)

Choline derivatives: Suxamethonium (Succinylcholine)

Polyalkylene derivatives: Hexamethonium
Centrally acting
Other
Directly acting

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)