LY6E

Lymphocyte antigen 6 complex, locus E

Identifiers

LY6E; RIG-E; RIGE; SCA-2; SCA2; TSA-1

External IDs

OMIM: 601384 MGI: 106651 HomoloGene: 56411 GeneCards: LY6E Gene

Gene Ontology
Molecular function	• GPI anchor binding
Cellular component	• plasma membrane • integral to plasma membrane • anchored to membrane
Biological process	• in utero embryonic development • cell surface receptor linked signaling pathway • adrenal gland development • organ growth • norepinephrine metabolic process • epinephrine secretion • ventricular cardiac muscle tissue morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
144.1 – 144.11 Mb

Chr 15:
74.79 – 74.79 Mb

PubMed search

[1]

[2]

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.^[1]^[2]^[3]

References

^ Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol 157 (3): 969–73. PMID 8757598.
^ Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC 39161. PMID 8650192. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39161.
^ "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4061.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB (1997). "A gain of novel tissue specificity in the human Ly-6 gene E48". J. Immunol. 159 (10): 4879–86. PMID 9366413.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Shan X, Bourdeau A, Rhoton A et al. (1998). "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1". J. Immunol. 160 (1): 197–208. PMID 9551972.
Kosugi A, Saitoh S, Noda S et al. (1998). "Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex". J. Biol. Chem. 273 (20): 12301–6. doi:10.1074/jbc.273.20.12301. PMID 9575182.
Ding L, Shevach EM (2001). "Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen". Immunology 104 (1): 28–36. doi:10.1046/j.1365-2567.2001.01275.x. PMC 1783287. PMID 11576217. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1783287.
Tulin EE, Onoda N, Nakata Y et al. (2002). "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation". J. Immunol. 167 (11): 6338–47. PMID 11714798.
Zammit DJ, Berzins SP, Gill JW et al. (2002). "Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland". Mol. Cell. Biol. 22 (3): 946–52. doi:10.1128/MCB.22.3.946-952.2002. PMC 133557. PMID 11784869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133557.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
de Nooij-van Dalen AG (2003). "Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma". Int. J. Cancer 103 (6): 768–74. doi:10.1002/ijc.10903. PMID 12516096.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

LY6E

References

Further reading