LRRC4

Leucine rich repeat containing 4

PDB rendering based on 2dl9.

Available structures
PDB	2dl9

Identifiers

Symbols

LRRC4; MGC133342; MGC133343; NGL-2

External IDs

OMIM: 610486 MGI: 2182081 HomoloGene: 36403 GeneCards: LRRC4 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• plasma membrane • integral to membrane • cell junction • synapse • postsynaptic membrane
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
127.67 – 127.67 Mb

Chr 6:
28.61 – 28.78 Mb

PubMed search

[1]

[2]

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.^[1]^[2]

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.^[2]

References

^ Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY (Sep 2003). "Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251". Ai Zheng 22 (9): 897–902. PMID 12969517.
^ ^a ^b "Entrez Gene: LRRC4 leucine rich repeat containing 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64101.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakashiba T, Ikeda T, Nishimura S, et al. (2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.". J. Neurosci. 20 (17): 6540–50. PMID 10964959.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Lin JC, Ho WH, Gurney A, Rosenthal A (2004). "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.". Nat. Neurosci. 6 (12): 1270–6. doi:10.1038/nn1148. PMID 14595443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Zhang Q, Wang J, Fan S, et al. (2005). "Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily.". FEBS Lett. 579 (17): 3674–82. doi:10.1016/j.febslet.2005.05.058. PMID 15967442.
Zhang QH, Wang LL, Cao L, et al. (2005). "Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system.". Acta Biochim. Biophys. Sin. (Shanghai) 37 (8): 532–40. doi:10.1111/j.1745-7270.2005.00079.x. PMID 16077900.
Fan SQ, Wang JR, Huang H, et al. (2007). "[Function of a novel brain-specific gene LRRC4]". Zhonghua Zhong Liu Za Zhi 27 (7): 393–6. PMID 16188120.
Zhang QH, Wu MH, Wang LL, et al. (2005). "Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array.". Acta Biochim. Biophys. Sin. (Shanghai) 37 (10): 680–7. doi:10.1111/j.1745-7270.2005.00100.x. PMID 16215635.
Wu M, Huang C, Gan K, et al. (2006). "LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway.". Mol. Biol. Cell 17 (8): 3534–42. doi:10.1091/mbc.E05-11-1082. PMC 1525233. PMID 16723503. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1525233.
Wu M, Gan K, Huang C, et al. (2007). "LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression.". J. Neurooncol. 80 (2): 133–42. doi:10.1007/s11060-006-9173-6. PMID 16941076.
Wu M, Huang C, Li X, et al. (2007). "LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.". J. Cell. Physiol. 214 (1): 65–74. doi:10.1002/jcp.21163. PMID 17541939.

PDB gallery

2dl9: Solution structure of the Ig-like domain of human Leucine-rich repeat-containing protein 4

LRRC4

References

Further reading