LRRC16A

leucine rich repeat containing 16A
Identifiers
Symbol LRRC16A
Alt. symbols LRRC16
Entrez 55604
HUGO 21581
OMIM 609593
RefSeq NM_017640
UniProt Q5VZK9
Other data
Locus Chr. 6 p22.1

Leucine rich repeat containing 16A is a protein that in humans is encoded by the LRRC16A gene.[1] The gene is also known as LRRC16, CARMIL, CARMIL1 or CARMIL1a.[1]

Model organisms

Model organisms have been used in the study of LRRC16A function. A conditional knockout mouse line, called Lrrc16atm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty two tests were carried out on mutant mice but no significant abnormalities were observed.[4]

References

  1. ^ a b "leucine rich repeat containing 16A". http://www.ncbi.nlm.nih.gov/gene/55604. Retrieved 2011-12-04. 
  2. ^ "Salmonella infection data for Lrrc16a". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MBKM/salmonella-challenge/. 
  3. ^ "Citrobacter infection data for Lrrc16a". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MBKM/citrobacter-challenge/. 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.4142.x/abstract. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Lrrc16a. 
  7. ^ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4362921. 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750.  edit
  9. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474: 262-263. doi:10.1038/474262a. http://www.nature.com/news/2011/110615/full/474262a.html. 
  10. ^ Collins FS, Rossant J, Wurst W (January 2007). A mouse for all reasons. Cell 128(1): 9-13. doi:10.1016/j.cell.2006.12.018 PMID 17218247. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMID 21722353. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21722353. 

Further reading