LRP6

Low density lipoprotein receptor-related protein 6

Identifiers

LRP6; ADCAD2; FLJ90062; FLJ90421

External IDs

OMIM: 603507 MGI: 1298218 HomoloGene: 1747 GeneCards: LRP6 Gene

Gene Ontology
Molecular function	• low-density lipoprotein receptor activity • receptor binding • frizzled binding • protein binding • coreceptor activity • Wnt-protein binding • kinase inhibitor activity • toxin transporter activity • toxin transporter activity • apolipoprotein binding • protein homodimerization activity
Cellular component	• membrane fraction • early endosome • endoplasmic reticulum • plasma membrane • caveola • cell surface • integral to membrane • cytoplasmic vesicle
Biological process	• neural tube closure • negative regulation of protein phosphorylation • heart looping • positive regulation of mesenchymal cell proliferation • pericardium morphogenesis • negative regulation of protein kinase activity • endocytosis • multicellular organismal development • embryonic pattern specification • neural crest formation • neural crest cell differentiation • Wnt receptor signaling pathway • Wnt receptor signaling pathway • cerebellum morphogenesis • thalamus development • cerebral cortex cell migration • forebrain radial glial cell differentiation • Wnt receptor signaling pathway involved in forebrain neuroblast division • neural tube development • formation of radial glial scaffolds • midbrain development • midbrain-hindbrain boundary development • negative regulation of smooth muscle cell apoptosis • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • tail morphogenesis • external genitalia morphogenesis • cell migration involved in gastrulation • odontogenesis of dentine-containing tooth • embryonic digit morphogenesis • positive regulation of apoptosis • Wnt receptor signaling pathway involved in dorsal/ventral axis specification • canonical Wnt receptor signaling pathway involved in neural crest cell differentiation • canonical Wnt receptor signaling pathway involved in regulation of cell proliferation • negative regulation of fat cell differentiation • positive regulation of ossification • positive regulation of bone resorption • positive regulation of cell cycle • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • bone remodeling • embryonic camera-type eye morphogenesis • skeletal system morphogenesis • negative regulation of epithelial cell proliferation • positive regulation of sequence-specific DNA binding transcription factor activity • response to folic acid • palate development • convergent extension • embryonic retina morphogenesis in camera-type eye • canonical Wnt receptor signaling pathway • canonical Wnt receptor signaling pathway • regulation of cell development • face morphogenesis • branching involved in mammary gland duct morphogenesis • trachea cartilage morphogenesis • mammary placode formation • canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development • canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation • cellular response to cholesterol • dopaminergic neuron differentiation • negative regulation of protein serine/threonine kinase activity • primitive streak formation • receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport • Wnt receptor signaling pathway involved in somitogenesis • axis elongation involved in somitogenesis • positive regulation of canonical Wnt receptor signaling pathway • positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification • negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis • negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis • negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis • negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis • negative regulation of planar cell polarity pathway involved in pericardium morphogenesis • negative regulation of planar cell polarity pathway involved in neural tube closure
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
12.27 – 12.42 Mb

Chr 6:
134.4 – 134.52 Mb

PubMed search

[1]

[2]

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene.^[1]^[2]

Interactions

LRP6 has been shown to interact with DKK1.^[3]

References

^ Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF (Sep 1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem Biophys Res Commun 248 (3): 879–88. doi:10.1006/bbrc.1998.9061. PMID 9704021.
^ "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4040.
^ Semënov, M V; Tamai K, Brott B K, Kühl M, Sokol S, He X (Jun. 2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. (England) 11 (12): 951–61. doi:10.1016/S0960-9822(01)00290-1. ISSN 0960-9822. PMID 11448771.

LRP6

Interactions

References

Further reading