LOXL3

Lysyl oxidase-like 3

Identifiers

External IDs

OMIM: 607163 MGI: 1337004 HomoloGene: 56591 GeneCards: LOXL3 Gene

Gene Ontology
Molecular function	• protein-lysine 6-oxidase activity • scavenger receptor activity • copper ion binding • oxidoreductase activity • metal ion binding
Cellular component	• extracellular region • extracellular space • membrane
Biological process	• biological_process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
74.76 – 74.78 Mb

Chr 6:
82.98 – 83 Mb

PubMed search

[1]

[2]

Lysyl oxidase homolog 3 is an enzyme that in humans is encoded by the LOXL3 gene.^[1]^[2]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.^[2]

References

^ Jourdan-Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K (Jun 2001). "Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein". Genomics 74 (2): 211–8. doi:10.1006/geno.2001.6545. PMID 11386757.
^ ^a ^b "Entrez Gene: LOXL3 lysyl oxidase-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84695.

Molnar J, Fong KS, He QP et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins". Biochim. Biophys. Acta 1647 (1–2): 220–4. PMID 12686136.
Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family". Prog. Nucleic Acid Res. Mol. Biol.. Progress in Nucleic Acid Research and Molecular Biology 70: 1–32. doi:10.1016/S0079-6603(01)70012-8. ISBN 978-0-12-540070-1. PMID 11642359.
Akagawa H, Narita A, Yamada H et al. (2007). "Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms". Hum. Genet. 121 (3–4): 377–87. doi:10.1007/s00439-007-0333-3. PMID 17287949.
Lee JE, Kim Y (2007). "A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity". J. Biol. Chem. 281 (49): 37282–90. doi:10.1074/jbc.M600977200. PMID 17018530.
Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D et al. (2006). "A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression". EMBO J. 24 (19): 3446–58. doi:10.1038/sj.emboj.7600781. PMC 1276164. PMID 16096638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1276164.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Huang Y, Dai J, Tang R et al. (2001). "Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)". Matrix Biol. 20 (2): 153–7. doi:10.1016/S0945-053X(01)00124-X. PMID 11334717.
Mäki JM, Kivirikko KI (2001). "Cloning and characterization of a fourth human lysyl oxidase isoenzyme". Biochem. J. 355 (Pt 2): 381–7. doi:10.1042/0264-6021:3550381. PMC 1221749. PMID 11284725. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221749.

LOXL3

See also

References

Further reading