LOXL2

Lysyl oxidase-like 2
Identifiers
Symbols LOXL2; LOR2; WS9-14
External IDs OMIM606663 MGI2137913 HomoloGene1742 GeneCards: LOXL2 Gene
EC number 1.4.3.-
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4017 94352
Ensembl ENSG00000134013 ENSMUSG00000034205
UniProt Q9Y4K0 Q5PR71
RefSeq (mRNA) NM_002318 NM_033325.2
RefSeq (protein) NP_002309 NP_201582.2
Location (UCSC) Chr 8:
23.15 – 23.28 Mb
Chr 14:
70.01 – 70.1 Mb
PubMed search [1] [2]

Lysyl oxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene.[1][2]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.[2] According to a BBC article on 2/22/11, "scientists at the UK's Institute of Cancer Research have prevented breast cancer spreading to other organs in mice by blocking the enzyme LOXL2 ". Their findings were published in Cancer Research. The authors found that LOXL2 was important in the early stages of cancer spread and that high levels of the enzyme were linked with cancer spread and poor survival rates so they used chemicals and antibodies to block the enzyme and stopped the metastasis.[3]

See also

References

  1. ^ Jourdan-Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K (Nov 1998). "The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3". Genomics 51 (2): 305–7. doi:10.1006/geno.1998.5356. PMID 9722957. 
  2. ^ a b "Entrez Gene: LOXL2 lysyl oxidase-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4017. 
  3. ^ "Blocking enzyme cut cancer spread". BBC News. 22 February 2011. http://www.bbc.co.uk/news/health-12525109. 

Further reading