LNX1

Ligand of numb-protein X 1

Identifiers

LNX1; LNX; MPDZ; PDZRN2

External IDs

OMIM: 609732 MGI: 1278335 HomoloGene: 7819 GeneCards: LNX1 Gene

6.3.2.19

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • PDZ domain binding • metal ion binding
Cellular component	• cytoplasm
Biological process	• protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein homooligomerization
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
54.33 – 54.57 Mb

Chr 5:
74.99 – 75.1 Mb

PubMed search

[1]

[2]

E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.^[1]^[2]^[3]

Interactions

LNX1 has been shown to interact with NAGK,^[4] NUMB^[2] and PAFAH1B3.^[4]

References

^ Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Aug 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochem Genet 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506.
^ ^a ^b Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". EMBO J 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125803.
^ "Entrez Gene: LNX1 ligand of numb-protein X 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84708.
^ ^a ^b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Dho SE, Jacob S, Wolting CD et al. (1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX". J. Biol. Chem. 273 (15): 9179–87. doi:10.1074/jbc.273.15.9179. PMID 9535908.
Rice DS, Northcutt GM, Kurschner C (2002). "The Lnx family proteins function as molecular scaffolds for Numb family proteins". Mol. Cell. Neurosci. 18 (5): 525–40. doi:10.1006/mcne.2001.1024. PMID 11922143.
Sollerbrant K, Raschperger E, Mirza M et al. (2003). "The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)". J. Biol. Chem. 278 (9): 7439–44. doi:10.1074/jbc.M205927200. PMID 12468544.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Katoh M, Katoh M (2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico". Int. J. Mol. Med. 13 (4): 607–13. PMID 15010864.
Armbruester V, Sauter M, Roemer K et al. (2004). "Np9 Protein of Human Endogenous Retrovirus K Interacts with Ligand of Numb Protein X". J. Virol. 78 (19): 10310–9. doi:10.1128/JVI.78.19.10310-10319.2004. PMC 516385. PMID 15367597. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=516385.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Chen J, Xu J, Zhao W et al. (2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas". Int. J. Biochem. Cell Biol. 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Weiss A, Baumgartner M, Radziwill G et al. (2007). "c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1". FEBS Lett. 581 (26): 5131–6. doi:10.1016/j.febslet.2007.09.062. PMID 17936276.

LNX1

Interactions

References

Further reading