LMO3

LIM domain only 3 (rhombotin-like 2)
Identifiers
Symbols LMO3; DAT1; MGC26081; RBTN3; RBTNL2; RHOM3; Rhom-3
External IDs OMIM180386 MGI102810 HomoloGene38552 GeneCards: LMO3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 55885 109593
Ensembl ENSG00000048540 ENSMUSG00000030226
UniProt Q8TAP4 Q8K044
RefSeq (mRNA) NM_001001395.1 NM_207222.2
RefSeq (protein) NP_001001395.1 NP_997105.1
Location (UCSC) Chr 12:
16.7 – 16.76 Mb
Chr 6:
138.31 – 138.53 Mb
PubMed search [1] [2]

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.[1][2][3] LMO3 interacts with the tumor suppressor p53 and regulates its function.[4] LMO3 is considered to be an oncogene in Neuroblastoma.[5]

References

  1. ^ Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558. 
  2. ^ Shi, J; Cai, W; Chen, X; Ying, K; Zhang, K; Xie, Y (2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. 
  3. ^ EntrezGene 55885
  4. ^ Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558. 
  5. ^ Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558. 

Further reading