LIN7C

Lin-7 homolog C (C. elegans)

PDB rendering based on 2dkr.

Available structures
PDB	2dkr

Identifiers

Symbols

LIN7C; FLJ11215; LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3

External IDs

OMIM: 612332 MGI: 1330839 HomoloGene: 22649 GeneCards: LIN7C Gene

Gene Ontology
Molecular function	• protein domain specific binding • PDZ domain binding
Cellular component	• plasma membrane • cell-cell junction • tight junction • postsynaptic density • basolateral plasma membrane • synaptosome • synapse • postsynaptic membrane
Biological process	• exocytosis • neurotransmitter secretion • protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
27.52 – 27.53 Mb

Chr 2:
109.73 – 109.74 Mb

PubMed search

[1]

[2]

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.^[1]^[2]

Interactions

LIN7C has been shown to interact with KCNJ4,^[3]^[4] KCNJ12^[3]^[4] and DLG1.^[4]

References

^ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci 19 (11): 4189–99. PMID 10341223.
^ "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55327.
^ ^a ^b Leonoudakis, Dmitri; Conti Lisa R, Anderson Scott, Radeke Carolyn M, McGuire Leah M M, Adams Marvin E, Froehner Stanley C, Yates John R, Vandenberg Carol A (May. 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. (United States) 279 (21): 22331–46. doi:10.1074/jbc.M400285200. ISSN 0021-9258. PMID 15024025.
^ ^a ^b ^c Leonoudakis, Dmitri; Conti Lisa R, Radeke Carolyn M, McGuire Leah M M, Vandenberg Carol A (Apr. 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. (United States) 279 (18): 19051–63. doi:10.1074/jbc.M400284200. ISSN 0021-9258. PMID 14960569.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bécamel C, Alonso G, Galéotti N, et al. (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332–42. doi:10.1093/emboj/21.10.2332. PMC 126011. PMID 12006486. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126011.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Leonoudakis D, Conti LR, Radeke CM, et al. (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Petrosky KY, Ou HD, Löhr F, et al. (2006). "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes". J. Biol. Chem. 280 (46): 38528–36. doi:10.1074/jbc.M506536200. PMID 16147993.
Mendes CC, Gomes DA, Thompson M, et al. (2006). "The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol. Chem. 280 (49): 40892–900. doi:10.1074/jbc.M506623200. PMID 16192275.
Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J. Biol. Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
Onda T, Uzawa K, Nakashima D, et al. (2007). "Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma". Cancer Res. 67 (20): 9643–8. doi:10.1158/0008-5472.CAN-07-1911. PMID 17942893.

PDB gallery

2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B

LIN7C

Interactions

References

Further reading