LILRB5

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
Identifiers
Symbols LILRB5; CD85C; LIR-8; LIR8
External IDs OMIM: 604814 HomoloGene: 115648 GeneCards: LILRB5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10990 n/a
Ensembl ENSG00000105609 n/a
UniProt O75023 n/a
RefSeq (mRNA) NM_001081442.1 n/a
RefSeq (protein) NP_001074911.1 n/a
Location (UCSC) Chr 19:
54.75 – 54.76 Mb		 n/a
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.[1][2]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol 159 (11): 5192–6. PMID 9548455. 
  2. ^ a b "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10990. 

Further reading