LGALS8
Galectin-8 is a protein that in humans is encoded by the LGALS8 gene.[1][2][3]
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
Interactions
LGALS8 has been shown to interact with CD49d,[4] CD29[4] and CD49c.[4]
References
- ^ Hadari YR, Paz K, Dekel R, Mestrovic T, Accili D, Zick Y (Mar 1995). "Galectin-8. A new rat lectin, related to galectin-4". J Biol Chem 270 (7): 3447–53. doi:10.1074/jbc.270.7.3447. PMID 7852431.
- ^ Su ZZ, Lin J, Shen R, Fisher PE, Goldstein NI, Fisher PB (Aug 1996). "Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family". Proc Natl Acad Sci U S A 93 (14): 7252–7. doi:10.1073/pnas.93.14.7252. PMC 38969. PMID 8692978. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38969.
- ^ a b "Entrez Gene: LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3964.
- ^ a b c Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 ( Pt 13): 2385–97. ISSN 0021-9533. PMID 10852818.
Further reading
- Bidon N, Brichory F, Bourguet P, et al. (2001). "Galectin-8: a complex sub-family of galectins (Review)". Int. J. Mol. Med. 8 (3): 245–50. PMID 11494049.
- Danguy A, Camby I, Kiss R (2002). "Galectins and cancer". Biochim. Biophys. Acta 1572 (2–3): 285–93. PMID 12223276.
- Bidon-Wagner N, Le Pennec JP (2004). "Human galectin-8 isoforms and cancer". Glycoconj. J. 19 (7–9): 557–63. doi:10.1023/B:GLYC.0000014086.38343.98. PMID 14758080.
- Bassen R, Brichory F, Caulet-Maugendre S, et al. (2000). "Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues". Anticancer Res. 19 (6B): 5429–33. PMID 10697573.
- Hadari YR, Arbel-Goren R, Levy Y, et al. (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. 113 ( Pt 13): 2385–97. PMID 10852818.
- Gopalkrishnan RV, Roberts T, Tuli S, et al. (2000). "Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene". Oncogene 19 (38): 4405–16. doi:10.1038/sj.onc.1203767. PMID 10980616.
- Bidon N, Brichory F, Hanash S, et al. (2001). "Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line". Gene 274 (1–2): 253–62. doi:10.1016/S0378-1119(01)00598-4. PMID 11675018.
- Nagy N, Bronckart Y, Camby I, et al. (2002). "Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor". Gut 50 (3): 392–401. doi:10.1136/gut.50.3.392. PMC 1773143. PMID 11839721. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1773143.
- Maier C, Rösch K, Herkommer K, et al. (2003). "A candidate gene approach within the susceptibility region PCaP on 1q42.2-43 excludes deleterious mutations of the PCTA-1 gene to be responsible for hereditary prostate cancer". Eur. Urol. 42 (3): 301–7. doi:10.1016/S0302-2838(02)00280-4. PMID 12234517.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Levy Y, Ronen D, Bershadsky AD, Zick Y (2003). "Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin". J. Biol. Chem. 278 (16): 14533–42. doi:10.1074/jbc.M207380200. PMID 12569102.
- Ideo H, Seko A, Ishizuka I, Yamashita K (2004). "The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity". Glycobiology 13 (10): 713–23. doi:10.1093/glycob/cwg094. PMID 12851289.
- Nishi N, Shoji H, Seki M, et al. (2004). "Galectin-8 modulates neutrophil function via interaction with integrin alphaM". Glycobiology 13 (11): 755–63. doi:10.1093/glycob/cwg102. PMID 12881409.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Arbel-Goren R, Levy Y, Ronen D, Zick Y (2005). "Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8". J. Biol. Chem. 280 (19): 19105–14. doi:10.1074/jbc.M502060200. PMID 15753078.