LCOR

Ligand dependent nuclear receptor corepressor

PDB rendering based on 2cob.
Identifiers
Symbols LCOR; FLJ38026; KIAA1795; MLR2; RP11-175O19.1
External IDs OMIM607698 MGI2443930 HomoloGene18153 GeneCards: LCOR Gene
Orthologs
Species Human Mouse
Entrez 84458 212391
Ensembl ENSG00000196233 ENSMUSG00000025019
UniProt Q96JN0 Q6ZPI3
RefSeq (mRNA) NM_001170765.1 NM_172154.4
RefSeq (protein) NP_001164236.1 NP_742166.1
Location (UCSC) Chr 10:
98.59 – 98.74 Mb
Chr 19:
41.56 – 41.64 Mb
PubMed search [1] [2]

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.[1][2][3]

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[3]

References

  1. ^ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528. 
  2. ^ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. PMID 15193453. 
  3. ^ a b "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84458. 

Further reading