Kayonza is a small town in Kayonza district, Eastern Province, Rwanda.
The town is centred on a roundabout, where the road east from Kigali splits into the road running north to the Ugandan border, and the road south to Tanzania. It is a major transport hub because of this junction, where a sizeable taxi-minibus park and terminus offers the Okapi, Atraco and Stella express services. It is also used as an overnight rest stop for lorry (i.e., truck) drivers from Tanzania to Kigali and beyond. A small hotel provides basic accommodation, and there are two petrol pumps, a conference centre, a twice-weekly market and various bars and television halls.