KSR1

Kinase suppressor of ras 1

PDB rendering based on 1kbe.

Available structures
PDB	1kbe, 1kbf

Identifiers

KSR1; KSR; RSU2

External IDs

OMIM: 601132 MGI: 105051 HomoloGene: 8410 GeneCards: KSR1 Gene

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity, transferring phosphorus-containing groups • metal ion binding
Cellular component	• intracellular • cytoplasm • membrane
Biological process	• protein phosphorylation • Ras protein signal transduction • intracellular signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000141068

ENSMUSG00000018334

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
25.78 – 25.95 Mb

Chr 11:
78.83 – 78.96 Mb

PubMed search

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene.^[1]^[2]

References

^ Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM (Jan 1996). "KSR, a novel protein kinase required for RAS signal transduction". Cell 83 (6): 879–88. doi:10.1016/0092-8674(95)90204-X. PMID 8521512.
^ "Entrez Gene: KSR1 kinase suppressor of ras 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8844.

Further reading

Goettel JA, Liang D, Hilliard VC, et al. (2011). "KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1". Exp. Cell Res. 317 (4): 452–63. doi:10.1016/j.yexcr.2010.11.018. PMC 3038243. PMID 21144847. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3038243.
Kolesnick R, Xing HR (2004). "Inflammatory bowel disease reveals the kinase activity of KSR1". J. Clin. Invest. 114 (9): 1233–7. doi:10.1172/JCI200423437. PMC 524240. PMID 15520853. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524240.
Xing HR, Lozano J, Kolesnick R (2000). "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras". J. Biol. Chem. 275 (23): 17276–80. doi:10.1074/jbc.C900989199. PMID 10764733.
Roy F, Therrien M (2002). "MAP kinase module: the Ksr connection". Curr. Biol. 12 (9): R325–7. doi:10.1016/S0960-9822(02)00831-X. PMID 12007434.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Matheny SA, Chen C, Kortum RL, et al. (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature 427 (6971): 256–60. doi:10.1038/nature02237. PMID 14724641.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Kim M, Yan Y, Kortum RL, et al. (2005). "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity". Cancer Res. 65 (10): 3986–92. doi:10.1158/0008-5472.CAN-03-2334. PMID 15899786.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2610434.
Wang X, Wang TT, White JH, Studzinski GP (2006). "Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region". Oncogene 25 (53): 7078–85. doi:10.1038/sj.onc.1209697. PMC 2843694. PMID 16732322. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2843694.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1kbe: Solution structure of the cysteine-rich C1 domain of Kinase Suppressor of Ras

1kbf: Solution Structure of the Cysteine-Rich C1 Domain of Kinase Suppressor of Ras