KPNA5

Karyopherin alpha 5 (importin alpha 6)

Identifiers

KPNA5; IPOA6; SRP6

External IDs

OMIM: 604545 HomoloGene: 100813 GeneCards: KPNA5 Gene

Gene Ontology
Molecular function	• protein binding • protein transporter activity
Cellular component	• nucleus • nuclear pore • cytoplasm
Biological process	• NLS-bearing substrate import into nucleus • intracellular protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_002269.2

n/a

RefSeq (protein)

NP_002260.2

n/a

Location (UCSC)

Chr 6:
117 – 117.06 Mb

n/a

PubMed search

[1]

n/a

Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene.^[1]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus^[2]

References

^ Kohler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Jan 1998). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Lett 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085.
^ "Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3841.

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Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.". Mol. Med. 1 (2): 217–30. PMC 2229944. PMID 8529100. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2229944.
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KPNA5

References

Further reading