KLRC2
NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2 gene.[1][2]
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.[2]
Interactions
KLRC2 has been shown to interact with KLRD1.[3][4]
See also
References
Further reading
- Houchins JP, Yabe T, McSherry C, Bach FH (1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". J. Exp. Med. 173 (4): 1017–20. doi:10.1084/jem.173.4.1017. PMC 2190798. PMID 2007850. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190798.
- Yabe T, McSherry C, Bach FH et al. (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins". Immunogenetics 37 (6): 455–60. doi:10.1007/BF00222470. PMID 8436421.
- Houchins JP, Lanier LL, Niemi EC et al. (1997). "Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C". J. Immunol. 158 (8): 3603–9. PMID 9103421.
- Braud VM, Allan DS, O'Callaghan CA et al. (1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature 391 (6669): 795–9. doi:10.1038/35869. PMID 9486650.
- Lanier LL, Corliss B, Wu J, Phillips JH (1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors". Immunity 8 (6): 693–701. doi:10.1016/S1074-7613(00)80574-9. PMID 9655483.
- Glienke J, Sobanov Y, Brostjan C et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics 48 (3): 163–73. doi:10.1007/s002510050420. PMID 9683661.
- Ding Y, Sumitran S, Holgersson J (1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scand. J. Immunol. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637.
- Khakoo SI, Rajalingam R, Shum BP et al. (2000). "Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans". Immunity 12 (6): 687–98. doi:10.1016/S1074-7613(00)80219-8. PMID 10894168.
- Shum BP, Flodin LR, Muir DG et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes". J. Immunol. 168 (1): 240–52. PMID 11751968.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hikami K, Tsuchiya N, Yabe T, Tokunaga K (2003). "Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population". Genes Immun. 4 (2): 160–7. doi:10.1038/sj.gene.6363940. PMID 12618865.
- Miyashita R, Tsuchiya N, Hikami K et al. (2004). "Molecular genetic analyses of human NKG2C (KLRC2) gene deletion". Int. Immunol. 16 (1): 163–8. doi:10.1093/intimm/dxh013. PMID 14688071.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ortega C, Romero P, Palma A et al. (2005). "Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses". Immunol. Cell Biol. 82 (6): 587–95. doi:10.1111/j.0818-9641.2004.01284.x. PMID 15550116.
- Gumá M, Busch LK, Salazar-Fontana LI et al. (2005). "The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells". Eur. J. Immunol. 35 (7): 2071–80. doi:10.1002/eji.200425843. PMID 15940674.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50
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CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100
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