KIAA1967

Not to be confused with Deleted in Bladder Cancer 1 (DBC1).

KIAA1967

Identifiers

KIAA1967; DBC-1; DBC1; NET35; p30DBC

External IDs

OMIM: 607359 MGI: 2444228 HomoloGene: 10910 GeneCards: KIAA1967 Gene

Gene Ontology
Molecular function	• enzyme inhibitor activity • enzyme inhibitor activity • protein binding • enzyme binding
Cellular component	• nucleus • cytoplasm • mitochondrial matrix
Biological process	• apoptosis • positive regulation of apoptosis • negative regulation of catalytic activity • negative regulation of catalytic activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
22.46 – 22.48 Mb

Chr 14:
70.54 – 70.55 Mb

PubMed search

[1]

[2]

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.^[1]^[2]^[3]

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53.^[4]^[5] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.^[6]

References

^ "Entrez Gene: KIAA1967 KIAA1967". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57805.
^ Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
^ Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. doi:10.1073/pnas.212516099. PMC 129730. PMID 12370419. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129730.
^ Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature 451 (7178): 583–6. doi:10.1038/nature06500. PMID 18235501.
^ Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1". Nature 451 (7178): 587–90. doi:10.1038/nature06515. PMC 2866287. PMID 18235502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2866287.
^ Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites". Cell Cycle 7 (10): 1467–72. doi:10.4161/cc.7.10.5883. PMC 2423810. PMID 18418069. http://www.landesbioscience.com/journals/cc/abstract.php?id=5883.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Hamaguchi M, Meth JL, von Klitzing C, et al. (2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. doi:10.1073/pnas.212516099. PMC 129730. PMID 12370419. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129730.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Sundararajan R, Chen G, Mukherjee C, White E (2005). "Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling". Oncogene 24 (31): 4908–20. doi:10.1038/sj.onc.1208681. PMID 15824730.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach". Cell Cycle 6 (2): 205–17. doi:10.4161/cc.6.2.3742. PMID 17314511.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Trauernicht AM, Kim SJ, Kim NH, Boyer TG (2007). "Modulation of estrogen receptor alpha protein level and survival function by DBC-1". Mol. Endocrinol. 21 (7): 1526–36. doi:10.1210/me.2007-0064. PMID 17473282.

KIAA human genes

KIAA0020 · KIAA0101 · KIAA0157 · KIAA0174 · KIAA0182 · KIAA0196 · KIAA0243 · KIAA0274 · KIAA0319 · KIAA0368 · KIAA0409 · KIAA0430 · KIAA0460 · KIAA0515 · KIAA0802 · KIAA0859 · KIAA0895 · KIAA0999 · KIAA1012 · KIAA1109 · KIAA1166 · KIAA1199 · KIAA1219 · KIAA1267 · KIAA1279 · KIAA1303 · KIAA1333 · KIAA1377 · KIAA1524 · KIAA1539 · KIAA1683 · KIAA1826 · KIAA1949 · KIAA1967

KIAA1967

Function

References

Further reading