KIAA1303

Regulatory associated protein of MTOR, complex 1
Identifiers
Symbols RPTOR; KIAA1303; KOG1; Mip1
External IDs OMIM: 607130 MGI: 1921620 HomoloGene: 80210 GeneCards: RPTOR Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 57521 74370
Ensembl ENSG00000141564 ENSMUSG00000025583
UniProt Q8N122 Q6ZPU3
RefSeq (mRNA) NM_001163034.1 NM_028898.2
RefSeq (protein) NP_001156506.1 NP_083174.2
Location (UCSC) Chr 17:
78.52 – 78.94 Mb		 Chr 11:
119.46 – 119.76 Mb
PubMed search [1] [2]

Regulatory-associated protein of mTOR (raptor; KIAA1303) is an adapter protein that is encoded in humans by the RPTOR gene.[1][2][3] Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.

Interactions

Raptor has been shown to interact with mammalian target of rapamycin (mTOR),[2][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] RICTOR,[11] FKBP1A,[4][5] EIF4EBP1,[2][6][7][8][16][23][24][25] P70-S6 Kinase 1[2][7][16][26] and RHEB.[27]

References

  1. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. 
  2. ^ a b c d Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K (Aug 2002). "Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action". Cell 110 (2): 177–89. doi:10.1016/S0092-8674(02)00833-4. PMID 12150926. 
  3. ^ "Entrez Gene: KIAA1303 raptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57521. 
  4. ^ a b Jacinto, Estela; Loewith Robbie, Schmidt Anja, Lin Shuo, Rüegg Markus A, Hall Alan, Hall Michael N (Nov. 2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. (England) 6 (11): 1122–8. doi:10.1038/ncb1183. ISSN 1465-7392. PMID 15467718. 
  5. ^ a b Sarbassov, D D; Ali Siraj M, Kim Do-Hyung, Guertin David A, Latek Robert R, Erdjument-Bromage Hediye, Tempst Paul, Sabatini David M (Jul. 2004). "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton". Curr. Biol. (England) 14 (14): 1296–302. doi:10.1016/j.cub.2004.06.054. ISSN 0960-9822. PMID 15268862. 
  6. ^ a b Schalm, Stefanie S; Fingar Diane C, Sabatini David M, Blenis John (May. 2003). "TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function". Curr. Biol. (England) 13 (10): 797–806. doi:10.1016/S0960-9822(03)00329-4. ISSN 0960-9822. PMID 12747827. 
  7. ^ a b c Ha, Sang Hoon; Kim Do-Hyung, Kim Il-Shin, Kim Jung Hwan, Lee Mi Nam, Lee Hyun Ju, Kim Jong Heon, Jang Sung Key, Suh Pann-Ghill, Ryu Sung Ho (Dec. 2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals". Cell. Signal. (England) 18 (12): 2283–91. doi:10.1016/j.cellsig.2006.05.021. ISSN 0898-6568. PMID 16837165. 
  8. ^ a b Wang, Lifu; Rhodes Christopher J, Lawrence John C (Aug. 2006). "Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1". J. Biol. Chem. (United States) 281 (34): 24293–303. doi:10.1074/jbc.M603566200. ISSN 0021-9258. PMID 16798736. 
  9. ^ Frias, Maria A; Thoreen Carson C, Jaffe Jacob D, Schroder Wayne, Sculley Tom, Carr Steven A, Sabatini David M (Sep. 2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. (England) 16 (18): 1865–70. doi:10.1016/j.cub.2006.08.001. ISSN 0960-9822. PMID 16919458. 
  10. ^ Buerger, Claudia; DeVries Ben, Stambolic Vuk (Jun. 2006). "Localization of Rheb to the endomembrane is critical for its signaling function". Biochem. Biophys. Res. Commun. (United States) 344 (3): 869–80. doi:10.1016/j.bbrc.2006.03.220. ISSN 0006-291X. PMID 16631613. 
  11. ^ a b Jacinto, Estela; Facchinetti Valeria, Liu Dou, Soto Nelyn, Wei Shiniu, Jung Sung Yun, Huang Qiaojia, Qin Jun, Su Bing (Oct. 2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell (United States) 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. ISSN 0092-8674. PMID 16962653. 
  12. ^ McMahon, Lloyd P; Yue Wei, Santen Richard J, Lawrence John C (Jan. 2005). "Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex". Mol. Endocrinol. (United States) 19 (1): 175–83. doi:10.1210/me.2004-0305. ISSN 0888-8809. PMID 15459249. 
  13. ^ Oshiro, Noriko; Yoshino Ken-ichi, Hidayat Sujuti, Tokunaga Chiharu, Hara Kenta, Eguchi Satoshi, Avruch Joseph, Yonezawa Kazuyoshi (Apr. 2004). "Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function". Genes Cells (England) 9 (4): 359–66. doi:10.1111/j.1356-9597.2004.00727.x. ISSN 1356-9597. PMID 15066126. 
  14. ^ Kawai, Shuji; Enzan Hideaki, Hayashi Yoshihiro, Jin Yu-Lan, Guo Li-Mei, Miyazaki Eriko, Toi Makoto, Kuroda Naoto, Hiroi Makoto, Saibara Toshiji, Nakayama Hirofumi (Jul. 2003). "Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers". Virchows Arch. (Germany) 443 (1): 78–86. doi:10.1007/s00428-003-0804-4. ISSN 0945-6317. PMID 12719976. 
  15. ^ Choi, Kin Man; McMahon Lloyd P, Lawrence John C (May. 2003). "Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor". J. Biol. Chem. (United States) 278 (22): 19667–73. doi:10.1074/jbc.M301142200. ISSN 0021-9258. PMID 12665511. 
  16. ^ a b c Nojima, Hiroki; Tokunaga Chiharu, Eguchi Satoshi, Oshiro Noriko, Hidayat Sujuti, Yoshino Ken-ichi, Hara Kenta, Tanaka Noriaki, Avruch Joseph, Yonezawa Kazuyoshi (May. 2003). "The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif". J. Biol. Chem. (United States) 278 (18): 15461–4. doi:10.1074/jbc.C200665200. ISSN 0021-9258. PMID 12604610. 
  17. ^ Kim, Do-Hyung; Sarbassov D D, Ali Siraj M, King Jessie E, Latek Robert R, Erdjument-Bromage Hediye, Tempst Paul, Sabatini David M (Jul. 2002). "mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery". Cell (United States) 110 (2): 163–75. doi:10.1016/S0092-8674(02)00808-5. ISSN 0092-8674. PMID 12150925. 
  18. ^ Schieke, Stefan M; Phillips Darci, McCoy J Philip, Aponte Angel M, Shen Rong-Fong, Balaban Robert S, Finkel Toren (Sep. 2006). "The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity". J. Biol. Chem. (United States) 281 (37): 27643–52. doi:10.1074/jbc.M603536200. ISSN 0021-9258. PMID 16847060. 
  19. ^ Sarbassov, Dos D; Ali Siraj M, Sengupta Shomit, Sheen Joon-Ho, Hsu Peggy P, Bagley Alex F, Markhard Andrew L, Sabatini David M (Apr. 2006). "Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB". Mol. Cell (United States) 22 (2): 159–68. doi:10.1016/j.molcel.2006.03.029. ISSN 1097-2765. PMID 16603397. 
  20. ^ Tzatsos, Alexandros; Kandror Konstantin V (Jan. 2006). "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation". Mol. Cell. Biol. (United States) 26 (1): 63–76. doi:10.1128/MCB.26.1.63-76.2006. ISSN 0270-7306. PMC 1317643. PMID 16354680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1317643. 
  21. ^ Sarbassov, Dos D; Sabatini David M (Nov. 2005). "Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex". J. Biol. Chem. (United States) 280 (47): 39505–9. doi:10.1074/jbc.M506096200. ISSN 0021-9258. PMID 16183647. 
  22. ^ Yang, Qian; Inoki Ken, Ikenoue Tsuneo, Guan Kun-Liang (Oct. 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. (United States) 20 (20): 2820–32. doi:10.1101/gad.1461206. ISSN 0890-9369. PMC 1619946. PMID 17043309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1619946. 
  23. ^ Eguchi, Satoshi; Tokunaga Chiharu, Hidayat Sujuti, Oshiro Noriko, Yoshino Ken-ichi, Kikkawa Ushio, Yonezawa Kazuyoshi (Jul. 2006). "Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size". Genes Cells (England) 11 (7): 757–66. doi:10.1111/j.1365-2443.2006.00977.x. ISSN 1356-9597. PMID 16824195. 
  24. ^ Beugnet, Anne; Wang Xuemin, Proud Christopher G (Oct. 2003). "Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1". J. Biol. Chem. (United States) 278 (42): 40717–22. doi:10.1074/jbc.M308573200. ISSN 0021-9258. PMID 12912989. 
  25. ^ Wang, Xuemin; Beugnet Anne, Murakami Mirei, Yamanaka Shinya, Proud Christopher G (Apr. 2005). "Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins". Mol. Cell. Biol. (United States) 25 (7): 2558–72. doi:10.1128/MCB.25.7.2558-2572.2005. ISSN 0270-7306. PMC 1061630. PMID 15767663. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1061630. 
  26. ^ Ali, Siraj M; Sabatini David M (May. 2005). "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site". J. Biol. Chem. (United States) 280 (20): 19445–8. doi:10.1074/jbc.C500125200. ISSN 0021-9258. PMID 15809305. 
  27. ^ Long, Xiaomeng; Lin Yenshou, Ortiz-Vega Sara, Yonezawa Kazuyoshi, Avruch Joseph (Apr. 2005). "Rheb binds and regulates the mTOR kinase". Curr. Biol. (England) 15 (8): 702–13. doi:10.1016/j.cub.2005.02.053. ISSN 0960-9822. PMID 15854902. 

Further reading

KIAA human genes