KIAA0895 | |||||||
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Identifiers | |||||||
Symbol | KIAA0895 | ||||||
External IDs | MGI: 1915533 HomoloGene: 19280 GeneCards: KIAA0895 Gene | ||||||
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Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez | 23366 | 68283 | |||||
Ensembl | ENSG00000164542 | ENSMUSG00000036411 | |||||
UniProt | Q8NCT3 | Q7TQE7 | |||||
RefSeq (mRNA) | NM_001100425 | NM_026739 | |||||
RefSeq (protein) | NP_001093895 | NP_081015 | |||||
Location (UCSC) | Chr 7: 36.33 – 36.4 Mb |
Chr 9: 22.22 – 22.25 Mb |
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PubMed search | [1] | [2] |
KIAA0895 is a human gene that codes for a protein known as KIAA0895 protein or hypothetical protein LOC23366.[1][2] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.[3]
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The KIAA0895 gene is located at p14.2 on chromosome 7. It can be transcribed into 15 different transcript variants, which in turn can produce 13 different isoforms of the protein.[4] The genomic DNA is 65,976 [base pair]s long,[1] while the longest mRNA that it produces is 4463 bases long.
KIAA0895 is surrounded by the following genes on chromosome 7 [1]:
The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long.[5]
Domain of unknown function 1704 | |||||||||
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Identifiers | |||||||||
Symbol | DUF1704 | ||||||||
Pfam | PF08014 | ||||||||
InterPro | IPR012548 | ||||||||
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LOC23366 contains a protein domain of unknown function called DUF1704.[6]
It also contains a region of low complexity from position 120 to position 150 in the protein,[7] and an arginine-rich area from position 12 to position 51.[8]
The KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout its structure, particularly in the first half of the protein[9] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites.[10]
KIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.[11] It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.
KIAA0895 has one paralog in humans known as KIAA0895L.[12] Orthologs have been found in all mammals, and eukaryotes through T. thermophila.[13] The full list of organisms in which orthologs have been found is given below.
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