KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, also known as KDELR1, is a protein which in humans is encoded by the KDELR1 gene.[1][2]
Function
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes and binds the tetrapeptide-containing protein and then returns it to the ER. In yeast, the sorting receptor is encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.[2]
Interactions
KDELR1 has been shown to interact with ARFGAP1.[3][4]
See also
References
- ^ Lewis MJ, Pelham HR (November 1990). "A human homologue of the yeast HDEL receptor". Nature 348 (6297): 162–3. doi:10.1038/348162a0. PMID 2172835.
- ^ a b "Entrez Gene: KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10945.
- ^ Aoe, T; Cukierman E, Lee A, Cassel D, Peters P J, Hsu V W (Dec. 1997). "The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1". EMBO J. (ENGLAND) 16 (24): 7305–16. doi:10.1093/emboj/16.24.7305. ISSN 0261-4189. PMC 1170331. PMID 9405360. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170331.
- ^ Majoul, I; Straub M, Hell S W, Duden R, Söling H D (Jul. 2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell (United States) 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. ISSN 1534-5807. PMID 11703931.
Further reading
- Pelham HR (1997). "The dynamic organisation of the secretory pathway.". Cell Struct. Funct. 21 (5): 413–9. doi:10.1247/csf.21.413. PMID 9118249.
- Lewis MJ, Pelham HR (1992). "Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum.". Cell 68 (2): 353–64. doi:10.1016/0092-8674(92)90476-S. PMID 1310258.
- Lewis MJ, Pelham HR (1990). "A human homologue of the yeast HDEL receptor.". Nature 348 (6297): 162–3. doi:10.1038/348162a0. PMID 2172835.
- Townsley FM, Wilson DW, Pelham HR (1993). "Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport.". EMBO J. 12 (7): 2821–9. PMC 413532. PMID 8392934. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=413532.
- Aoe T, Cukierman E, Lee A, et al. (1998). "The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1.". EMBO J. 16 (24): 7305–16. doi:10.1093/emboj/16.24.7305. PMC 1170331. PMID 9405360. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170331.
- Smith JS, Tachibana I, Pohl U, et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region.". Genomics 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
- Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET.". Dev. Cell 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Yamamoto K, Hamada H, Shinkai H, et al. (2003). "The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades.". J. Biol. Chem. 278 (36): 34525–32. doi:10.1074/jbc.M304188200. PMID 12821650.
- Bard F, Mazelin L, Péchoux-Longin C, et al. (2004). "Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum.". J. Biol. Chem. 278 (47): 46601–6. doi:10.1074/jbc.M302221200. PMID 12975382.
- Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.