KATNA1
Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.[1][2]
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.[2]
References
Further reading
- McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules.". Cell 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885.
- McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes.". J. Cell. Sci. 109 ( Pt 3): 561–7. PMID 8907702.
- Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.". Cell 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
- Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron.". J. Cell Biol. 145 (2): 305–15. doi:10.1083/jcb.145.2.305. PMC 2133110. PMID 10209026. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133110.
- Syu LJ, Saltiel AR (1999). "Lipotransin: a novel docking protein for hormone-sensitive lipase.". Mol. Cell 4 (1): 109–15. doi:10.1016/S1097-2765(00)80192-6. PMID 10445032.
- McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.". J. Cell. Sci. 113 ( Pt 9): 1623–33. PMID 10751153.
- Buster D, McNally K, McNally FJ (2002). "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis.". J. Cell. Sci. 115 (Pt 5): 1083–92. PMID 11870226.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.