JunD

Jun D proto-oncogene
Identifiers
Symbols JUND;
External IDs OMIM: 165162 MGI: 96648 HomoloGene: 3910 GeneCards: JUND Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3727 16478
Ensembl ENSG00000130522 ENSMUSG00000071076
UniProt P17535 n/a
RefSeq (mRNA) NM_005354.4 NM_010592.4
RefSeq (protein) NP_005345.3 NP_034722.1
Location (UCSC) Chr 19:
18.39 – 18.39 Mb		 Chr 8:
73.22 – 73.22 Mb
PubMed search [1] [2]

Transcription factor jun-D is a protein that in humans is encoded by the JUND gene.[1][2]

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.[3]

Contents

Interactions

JunD has been shown to interact with ATF3,[4] MEN1,[5] DNA damage-inducible transcript 3[6] and BRCA1.[7]

See also

References

  1. ^ Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (Jul 1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res 18 (10): 3047–8. doi:10.1093/nar/18.10.3047. PMC 330838. PMID 2112242. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=330838. 
  2. ^ Berger I, Shaul Y (Jun 1991). "Structure and function of human jun-D". Oncogene 6 (4): 561–6. PMID 1903194. 
  3. ^ "Entrez Gene: JUND jun D proto-oncogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3727. 
  4. ^ Chu, H M; Tan Y, Kobierski L A, Balsam L B, Comb M J (Jan. 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Mol. Endocrinol. (UNITED STATES) 8 (1): 59–68. doi:10.1210/me.8.1.59. ISSN 0888-8809. PMID 8152431. 
  5. ^ Agarwal, S K; Guru S C, Heppner C, Erdos M R, Collins R M, Park S Y, Saggar S, Chandrasekharappa S C, Collins F S, Spiegel A M, Marx S J, Burns A L (Jan. 1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell (UNITED STATES) 96 (1): 143–52. doi:10.1016/S0092-8674(00)80967-8. ISSN 0092-8674. PMID 9989505. 
  6. ^ Ubeda, M; Vallejo M, Habener J F (Nov. 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMC 84780. PMID 10523647. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84780. 
  7. ^ Hu, Yan-Fen; Li Rong (Jun. 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMC 186344. PMID 12080089. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186344. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.