Journal of Medicinal Chemistry
The Journal of Medicinal Chemistry (usually abbreviated as J. Med. Chem.),[1] is a peer-reviewed scientific journal, published since 1959 by the American Chemical Society. It was originally published as the Journal of Medicinal and Pharmaceutical Chemistry, but changed its name in 1963 to the current title.[2]
Profs. Gunda I. Georg of the University of Minnesota and Shaomeng Wang of the University of Michigan are the Editors of the journal. They took over leadership from Prof. Philip S. Portoghese of the University of Minnesota in 2012. Prof. Portoghese had served as Editor in Chief from 1972 - 2011.[3]
The Journal of Medicinal Chemistry publishes original research on the correlation of molecular structure to biological activity with a focus on the relationships of chemistry to biological activity. The journal also publishes research in the following areas:
- Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.
- Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.
- Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.
- Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.
- Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.
- Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.
- Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.
- Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.
The Journal of Medicinal Chemistry garnered 52,858 total citations in 2010 with an impact factor of 5.207 and making it the highest impact and most cited journal in the field of medicinal chemistry.[4].
References
- ^ Home Page on ACS
- ^ [1]
- ^ Chemical & Engineering News
- ^ About the Journal of Medicinal Chemistry
External links