JWH-171

JWH-171
Systematic (IUPAC) name
1-([(1E)-3-pentylinden-1-ylidine]methyl)naphthalene
Clinical data
Pregnancy cat.  ?
Legal status Legal
Identifiers
ATC code  ?
Chemical data
Formula C25H24 
Mol. mass 324.457 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

JWH-171 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 51.0nM, making it slightly less potent than THC itself,[1] however JWH-171 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor.[2] It was discovered by, and named after, Dr. John W. Huffman.

See also

References

  1. ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X