| Systematic (IUPAC) name | |
|---|---|
| 1-hexyl-3-(naphthalen-1-oyl)indole | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Class B (UK), illegal in Sweden, I-N (Poland)[1] |
| Identifiers | |
| CAS number | 209414-08-4 |
| ATC code | ? |
| Chemical data | |
| Formula | C25H25NO |
| Mol. mass | 355.471 g/mol |
| SMILES | eMolecules & PubChem |
| (what is this?) (verify) |
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JWH-019 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N1-hexyl homologue of the more common synthetic cannabinoid compound JWH-018. Unlike the butyl homologue JWH-073 which is several times weaker than JWH-018, the hexyl homologue is only slightly less potent, although extending the chain one carbon longer to the heptyl homologue JWH-020 results in dramatic loss of activity. These results show that the optimum side chain length for CB1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds. This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole compounds as compared to the classical cannabinoids, and may be useful in characterising the active site of the CB1 and CB2 receptors.[2][3][4]
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In Poland, JWH-019 is I-N (Poland)[1]
JWH-019 is illegal in Sweden
JWH-019 is Class B in the United Kingdom.
JWH-019 is not controlled federally in the United States, however if intended for human consumption, possession or sales could possibly be prosecuted under the Federal Analog Act.
JWH-019 is illegal in the State of Virginia.[5]
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