Janus kinase 1

Janus kinase 1

Rendering based on PDB 3EYG.
Identifiers
Symbols JAK1; JAK1A; JAK1B; JTK3
External IDs OMIM147795 MGI96628 HomoloGene1678 GeneCards: JAK1 Gene
EC number 2.7.10.2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3716 16451
Ensembl ENSG00000162434 ENSMUSG00000028530
UniProt P23458 Q3TI10
RefSeq (mRNA) NM_002227.2 NM_146145.2
RefSeq (protein) NP_002218.2 NP_666257.2
Location (UCSC) Chr 1:
65.3 – 65.43 Mb
Chr 4:
100.82 – 100.94 Mb
PubMed search [1] [2]

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors.[1] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.[2] Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.[3]

Contents

Interactions

Janus kinase 1 has been shown to interact with PTPN11,[4][5] Glycoprotein 130,[6][7][8] Interleukin 10 receptor, alpha subunit,[9][10] ELP2,[11] STAT3,[12][13] Grb2,[14][15] STAT5A,[16] STAT5B,[16] IL2RB,[10][17][18][19][20] TNFRSF1A,[21][22] IRS1,[23][24] GNB2L1[25] and STAM2.[26][27]

References

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  2. ^ Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD (1998). "Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses". Cell 93 (3): 373–83. doi:10.1016/S0092-8674(00)81166-6. PMID 9590172. 
  3. ^ Christian Nordqvist. "Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor". Medical News Today. http://www.medicalnewstoday.com/articles/232761.php. 
  4. ^ Yin, T; Shen R, Feng G S, Yang Y C (Jan. 1997). "Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases". J. Biol. Chem. (UNITED STATES) 272 (2): 1032–7. doi:10.1074/jbc.272.2.1032. ISSN 0021-9258. PMID 8995399. 
  5. ^ Lehmann, Ute; Schmitz Jochen, Weissenbach Manuela, Sobota Radoslaw M, Hortner Michael, Friederichs Kerstin, Behrmann Iris, Tsiaris William, Sasaki Atsuo, Schneider-Mergener Jens, Yoshimura Akihiko, Neel Benjamin G, Heinrich Peter C, Schaper Fred (Jan. 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130". J. Biol. Chem. (United States) 278 (1): 661–71. doi:10.1074/jbc.M210552200. ISSN 0021-9258. PMID 12403768. 
  6. ^ Haan, C; Is'harc H, Hermanns H M, Schmitz-Van De Leur H, Kerr I M, Heinrich P C, Grötzinger J, Behrmann I (Oct. 2001). "Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction". J. Biol. Chem. (United States) 276 (40): 37451–8. doi:10.1074/jbc.M106135200. ISSN 0021-9258. PMID 11468294. 
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  10. ^ a b Usacheva, Anna; Kotenko Sergei, Witte Michael M, Colamonici Oscar R (Aug. 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. (United States) 169 (3): 1302–8. ISSN 0022-1767. PMID 12133952. 
  11. ^ Collum, R G; Brutsaert S, Lee G, Schindler C (Aug. 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (18): 10120–5. doi:10.1073/pnas.170192197. ISSN 0027-8424. PMC 27739. PMID 10954736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27739. 
  12. ^ Ueda, Takeshi; Bruchovsky Nicholas, Sadar Marianne D (Mar. 2002). "Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways". J. Biol. Chem. (United States) 277 (9): 7076–85. doi:10.1074/jbc.M108255200. ISSN 0021-9258. PMID 11751884. 
  13. ^ Spiekermann, K; Biethahn S, Wilde S, Hiddemann W, Alves F (Aug. 2001). "Constitutive activation of STAT transcription factors in acute myelogenous leukemia". Eur. J. Haematol. (Denmark) 67 (2): 63–71. ISSN 0902-4441. PMID 11722592. 
  14. ^ Kim, H; Lee Y H, Won J, Yun Y (Sep. 2001). "Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers". Biochem. Biophys. Res. Commun. (United States) 286 (5): 886–94. doi:10.1006/bbrc.2001.5496. ISSN 0006-291X. PMID 11527382. 
  15. ^ Giorgetti-Peraldi, S; Peyrade F, Baron V, Van Obberghen E (Dec. 1995). "Involvement of Janus kinases in the insulin signaling pathway". Eur. J. Biochem. (GERMANY) 234 (2): 656–60. doi:10.1111/j.1432-1033.1995.656_b.x. ISSN 0014-2956. PMID 8536716. 
  16. ^ a b Fujitani, Y; Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (Feb. 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene (ENGLAND) 14 (7): 751–61. doi:10.1038/sj.onc.1200907. ISSN 0950-9232. PMID 9047382. 
  17. ^ Miyazaki, T; Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Z J, Oishi I, Silvennoinen O, Witthuhn B A, Ihle J N (Nov. 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science (UNITED STATES) 266 (5187): 1045–7. doi:10.1126/science.7973659. ISSN 0036-8075. PMID 7973659. 
  18. ^ Russell, S M; Johnston J A, Noguchi M, Kawamura M, Bacon C M, Friedmann M, Berg M, McVicar D W, Witthuhn B A, Silvennoinen O (Nov. 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science (UNITED STATES) 266 (5187): 1042–5. doi:10.1126/science.7973658. ISSN 0036-8075. PMID 7973658. 
  19. ^ Zhu, M H; Berry J A, Russell S M, Leonard W J (Apr. 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta". J. Biol. Chem. (UNITED STATES) 273 (17): 10719–25. doi:10.1074/jbc.273.17.10719. ISSN 0021-9258. PMID 9553136. 
  20. ^ Migone, T S; Rodig S, Cacalano N A, Berg M, Schreiber R D, Leonard W J (Nov. 1998). "Functional Cooperation of the Interleukin-2 Receptor β Chain and Jak1 in Phosphatidylinositol 3-Kinase Recruitment and Phosphorylation". Mol. Cell. Biol. (UNITED STATES) 18 (11): 6416–22. ISSN 0270-7306. PMC 109227. PMID 9774657. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109227. 
  21. ^ Guo, D; Dunbar J D, Yang C H, Pfeffer L M, Donner D B (Mar. 1998). "Induction of Jak/STAT signaling by activation of the type 1 TNF receptor". J. Immunol. (UNITED STATES) 160 (6): 2742–50. ISSN 0022-1767. PMID 9510175. 
  22. ^ Miscia, Sebastiano; Marchisio Marco, Grilli Alfredo, Di Valerio Valentina, Centurione Lucia, Sabatino Giuseppe, Garaci Francesco, Zauli Giorgio, Bonvini Ezio, Di Baldassarre Angela (Jan. 2002). "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth Differ. (United States) 13 (1): 13–8. ISSN 1044-9523. PMID 11801527. 
  23. ^ Gual, P; Baron V, Lequoy V, Van Obberghen E (Mar. 1998). "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". Endocrinology (UNITED STATES) 139 (3): 884–93. doi:10.1210/en.139.3.884. ISSN 0013-7227. PMID 9492017. 
  24. ^ Johnston, J A; Wang L M, Hanson E P, Sun X J, White M F, Oakes S A, Pierce J H, O'Shea J J (Dec. 1995). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases". J. Biol. Chem. (UNITED STATES) 270 (48): 28527–30. doi:10.1074/jbc.270.48.28527. ISSN 0021-9258. PMID 7499365. 
  25. ^ Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R (Sep. 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323. 
  26. ^ Pandey, A; Fernandez M M, Steen H, Blagoev B, Nielsen M M, Roche S, Mann M, Lodish H F (Dec. 2000). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". J. Biol. Chem. (UNITED STATES) 275 (49): 38633–9. doi:10.1074/jbc.M007849200. ISSN 0021-9258. PMID 10993906. 
  27. ^ Endo, K; Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea J J, Sugamura K (Jul. 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Lett. (NETHERLANDS) 477 (1–2): 55–61. doi:10.1016/S0014-5793(00)01760-9. ISSN 0014-5793. PMID 10899310. 

Further reading

External links