JAG2

Jagged 2

Identifiers

JAG2; HJ2; SER2

External IDs

OMIM: 602570 MGI: 1098270 HomoloGene: 1677 GeneCards: JAG2 Gene

Gene Ontology
Molecular function	• Notch binding • calcium ion binding • protein binding • growth factor activity
Cellular component	• membrane fraction • plasma membrane • integral to plasma membrane
Biological process	• skeletal system development • in utero embryonic development • respiratory system process • cell cycle • cell communication • Notch signaling pathway • Notch signaling pathway • Notch receptor processing • multicellular organismal development • spermatogenesis • auditory receptor cell fate commitment • morphogenesis of embryonic epithelium • cell differentiation • regulation of cell adhesion • T cell differentiation • regulation of cell migration • regulation of cell proliferation • odontogenesis of dentine-containing tooth • gamma-delta T cell differentiation • regulation of apoptosis • thymic T cell selection
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
105.61 – 105.64 Mb

Chr 12:
114.15 – 114.17 Mb

PubMed search

[1]

[2]

Protein jagged-2 is a protein that in humans is encoded by the JAG2 gene.^[1]^[2]^[3]

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

JAG2 has been shown to interact with NOTCH2.^[4]

References

^ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (Oct 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol 17 (10): 6057–67. PMC 232455. PMID 9315665. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232455.
^ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (Apr 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.
^ ^a ^b "Entrez Gene: JAG2 jagged 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3714.
^ Shimizu, K; Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (Sep. 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767.

Shawber C, Boulter J, Lindsell CE, Weinmaster G (1997). "Jagged2: a serrate-like gene expressed during rat embryogenesis". Dev. Biol. 180 (1): 370–6. doi:10.1006/dbio.1996.0310. PMID 8948600.
Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI (1998). "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions". Mech. Dev. 69 (1–2): 203–7. doi:10.1016/S0925-4773(97)00146-9. PMID 9486542.
Gray GE, Mann RS, Mitsiadis E, et al. (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1866435.
Lanford PJ, Lan Y, Jiang R, et al. (1999). "Notch signalling pathway mediates hair cell development in mammalian cochlea". Nat. Genet. 21 (3): 289–92. doi:10.1038/6804. PMID 10080181.
Felli MP, Maroder M, Mitsiadis TA, et al. (1999). "Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development". Int. Immunol. 11 (7): 1017–25. doi:10.1093/intimm/11.7.1017. PMID 10383933.
Tsai S, Fero J, Bartelmez S (2000). "Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood 96 (3): 950–7. PMID 10910909.
Shimizu K, Chiba S, Hosoya N, et al. (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767.
Shimizu K, Chiba S, Saito T, et al. (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. Physiol. 185 (3): 425–31. doi:10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U. PMID 11056013.
Lindner V, Booth C, Prudovsky I, et al. (2001). "Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction". Am. J. Pathol. 159 (3): 875–83. doi:10.1016/S0002-9440(10)61763-4. PMC 1850458. PMID 11549580. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850458.
Hayashi T, Kageyama Y, Ishizaka K, et al. (2002). "Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes". J. Androl. 22 (6): 999–1011. PMID 11700865.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ikeuchi T, Sisodia SS (2003). "The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200. PMID 12551931.
Houde C, Li Y, Song L, et al. (2004). "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood 104 (12): 3697–704. doi:10.1182/blood-2003-12-4114. PMID 15292061.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

Signaling pathway: notch signaling pathway

Receptor on signaling cell	Delta: DLL1 · DLL3 · DLL4

Ligand	Jagged: JAG1 · JAG2

Receptor on receiving cell	NOTCH1 · NOTCH2 · NOTCH3 · NOTCH4

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

JAG2

Interactions

References

Further reading