| Isosorbide | |
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Other names
D-Isosorbide; 1,4:3,6-Dianhydro-D-sorbitol; 1,4-Dianhydrosorbitol |
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| Identifiers | |
| CAS number | 652-67-5 |
| PubChem | 12597 |
| ChemSpider | 12077 |
| KEGG | D00347 |
| ChEMBL | CHEMBL1200660 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C6H10O4 |
| Molar mass | 146.14 g mol−1 |
| Appearance | Colorless solid |
| Melting point |
60-63 °C, 333-336 K, 140-145 °F |
| Boiling point |
decomp |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Isosorbide is a heterocyclic compound derived from glucose and is thus a biofeedstock. Glucose can be hydrogenated to sorbitol, which upon double dehydration gives isosorbide.
Isosorbide is a used as a diuretic used mainly to treat hydrocephalus and is also used to treat glaucoma.[1]
Other medications are derived from isosorbide, including isosorbide dinitrate and isosorbide mononitrate, are used to treat angina pectoris. Other isosorbide-based medicines are used as osmotic diuretics and for treatment of esophageal varices. Like other nitric oxide donors (see biological functions of nitric oxide), these drugs lower portal pressure by vasodilation and decreasing cardiac output. Isosorbide dinitrate and hydralazine are the two components of the anti-hypertensive drug bidil.