Iodophenpropit

Iodophenpropit
IUPAC name

3-(1H-imidazol-5-yl)propyl N'-[2-(4-iodophenyl)ethyl]imidothiocarbamate
Other names

1-[3-(3H-imidazol-4-yl)propylthio]-N'-[2-(4-iodophenyl)ethyl]formamidine
Identifiers
CAS number 143407-29-8 Y
PubChem 3035746
MeSH Iodophenpropit
ChEMBL CHEMBL498770 N
Jmol-3D images Image 1
Properties
Molecular formula C15H19IN4S
Molar mass 414.30763
 N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Iodophenpropit is a histamine antagonist which binds selectively to the H3 subtype. Its 125I radiolabelled form is used for mapping the distribution of H3 receptors in the body.[1][2]

References

  1. ^ Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). "Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain". British journal of pharmacology 113 (2): 355–62. PMC 1510107. PMID 7834183. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1510107. 
  2. ^ Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's archives of pharmacology 362 (1): 60–7. doi:10.1007/s002100000227. PMID 10935534.