| Interleukin 9 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | IL9; HP40; IL-9; P40 | ||||||||||||
| External IDs | OMIM: 146931 MGI: 96563 HomoloGene: 492 GeneCards: IL9 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3578 | 16198 | |||||||||||
| Ensembl | ENSG00000145839 | ENSMUSG00000021538 | |||||||||||
| UniProt | P15248 | P15247 | |||||||||||
| RefSeq (mRNA) | NM_000590.1 | NM_008373.1 | |||||||||||
| RefSeq (protein) | NP_000581.1 | NP_032399.1 | |||||||||||
| Location (UCSC) | Chr 5: 135.23 – 135.23 Mb |
Chr 13: 56.58 – 56.58 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Interleukin 9, also known as IL9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.[1]
The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.[1]
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