Inflammatory myofibroblastic tumour

Inflammatory myofibroblastic tumour
Classification and external resources

Micrograph of an inflammatory myofibroblastic tumour of the kidney. Kidney biopsy. H&E stain.
ICD-O: M8825/1

Inflammatory myofibroblastic tumour, also known as inflammatory pseudotumour, plasma cell granuloma,[1] and inflammatory fibrosarcoma, is a soft tissue lesion that may be confused with a sarcoma. It is abbreviated IMT.

Contents

Symptoms

The symptoms depend on the specific location of the tumour, which can be anywhere in the body.[2]

Diagnosis

Inflammatory myofibroblastic tumours are diagnosed based on their appearance under the microscope, by pathologists.[3] Medical imaging findings are non-specific.

Pathology

Inflammatory myofibroblastic tumours are characterized by a mix of inflammatory cells, e.g. plasma cells, lymphocytes and eosinophils, and bland spindle cells without nuclear atypia. These tumours may have necrosis, hemorrhage, focal calcification and mitotic activity.

The histologic differential diagnosis includes calcifying fibrous pseudotumour, inflammatory fibroid tumour and nodular fasciitis.

Approximately half of IMTs have a rearrangement of the ALK gene.[4]

See also

References

  1. ^ Manohar, B.; Bhuvaneshwari, S. (Jan 2011). "Plasma cell granuloma of gingiva.". J Indian Soc Periodontol 15 (1): 64-6. doi:10.4103/0972-124X.82275. PMID 21772725. 
  2. ^ Singhal, M.; Ramanathan, S.; Das, A.; Singh, G.; Bagga, R.; Khandelwal, N. (2011). "Omental inflammatory myofibroblastic tumour mimicking peritoneal carcinomatosis.". Cancer Imaging 11: 19-22. doi:10.1102/1470-7330.2011.0005. PMID 21435987. 
  3. ^ Soga, H.; Yao, A.; Matsushita, K.; Shimogaki, H.; Kawabata, G.. "Inflammatory pseudotumor of the retroperitoneum removed via a retroperitoneoscopic approach.". JSLS 15 (2): 272-4. doi:10.4293/108680811X13071180406871. PMID 21902993. 
  4. ^ Gleason, BC.; Hornick, JL. (Apr 2008). "Inflammatory myofibroblastic tumours: where are we now?". J Clin Pathol 61 (4): 428-37. doi:10.1136/jcp.2007.049387. PMID 17938159.