Combination of | |
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Imipenem | Carbapenem antibiotic |
Cilastatin | Dehydropeptidase inhibitor |
Clinical data | |
MedlinePlus | a605011 |
Pregnancy cat. | C(US) |
Legal status | POM (UK) ℞-only (US) |
Routes | Intravenous, intramuscular |
Identifiers | |
CAS number | 92309-29-0 |
ATC code | J01DH51 |
PubChem | CID 11954222 |
ChemSpider | 21106325 |
ChEMBL | CHEMBL296854 |
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Imipenem/cilastatin (marketed as Primaxin in the USA) is a broad spectrum beta-lactam antibiotic containing equal quantities of imipenem and cilastatin. It is related to the penicillin/cephalosporin family of antibiotics but is classified as belonging to the carbapenem class.
Contents |
It has the ability to kill a wide variety of bacteria. It works by interfering with their ability to form cell walls, and therefore the bacteria break up and die.
Imipenem/cilastatin is marketed by Merck & Co. under the trade names Primaxin, Tienam and Zienam. The combination is also marketed by Ranbaxy Laboratories in India under the brand name Cilanem. It is also marketed by Highnoon Laboratories Ltd. in Pakistan under the trade name Prepenem. Prepenem was launched by Highnoon in May 2007 and was the first generic brand after the research brand Tienam.
Imipenem/cilastatin is known to cause seizures.