Idursulfase

Idursulfase (brand name Elaprase) is a drug used to treat Hunter syndrome (also called Mucopolysaccharoidosis II).^[1] It is a purified form of the lysosomal enzyme iduronate-2-sulfatase and is produced by recombinant DNA technology in a human cell line.

It is one of the most expensive drugs ever produced, costing $375,000 per year.^[2][3]

It is manufactured by Shire Pharmaceuticals Group.

References

1. ^ Garcia AR, DaCosta JM, Pan J, Muenzer J, Lamsa JC (2007). "Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II". Mol. Genet. Metab. 91 (2): 183–90. doi:10.1016/j.ymgme.2007.03.003. PMID 17459751. 
2. ^ "Drug approved to treat rare but potentially deadly disease". http://www.mediadoctor.ca/content/article.jsp?intArticleID=293. Retrieved 2011-04-29. 
3. ^ Health Care: The World's Most Expensive Drugs, Matthew Herper, Forbes, Feb. 22, 2010

External links

• MeSH idursulfase