ITIH4

Inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

Identifiers

ITIH4; DKFZp686G21125; GP120; H4P; IHRP; ITI-HC4; ITIHL1; PK-120; PK120

External IDs

OMIM: 600564 MGI: 109536 HomoloGene: 1670 GeneCards: ITIH4 Gene

Gene Ontology
Molecular function	• endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity
Cellular component	• extracellular region
Biological process	• acute-phase response • negative regulation of endopeptidase activity • hyaluronan metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
52.85 – 52.87 Mb

Chr 14:
31.7 – 31.72 Mb

PubMed search

[1]

[2]

Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ITIH4 gene.^[1]^[2]^[3]

References

^ Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler JL, Salier JP (Mar 1998). "The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human". Biochem Biophys Res Commun 243 (2): 522–30. doi:10.1006/bbrc.1998.8128. PMID 9480842.
^ Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (Feb 1995). "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein". FEBS Lett 357 (2): 207–11. doi:10.1016/0014-5793(94)01364-7. PMID 7805892.
^ "Entrez Gene: ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3700.

Choi-Miura NH, Sano Y, Oda E, et al. (1995). "Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma.". J. Biochem. 117 (2): 400–7. doi:10.1093/jb/117.2.400. PMID 7541790.
Tobe T, Saguchi K, Hashimoto K, et al. (1995). "Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21→p14.". Cytogenet. Cell Genet. 71 (3): 296–8. doi:10.1159/000134130. PMID 7587397.
Saguchi K, Tobe T, Hashimoto K, et al. (1995). "Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein.". J. Biochem. 117 (1): 14–8. PMID 7775381.
Saguchi K, Tobe T, Hashimoto K, et al. (1997). "Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1).". J. Biochem. 119 (5): 898–905. PMID 8797089.
Jean L, Smih F, Olivier E, et al. (1997). "Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14.". Genomics 41 (1): 139–40. doi:10.1006/geno.1997.4612. PMID 9126497.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage.". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.
Tozaki T, Choi-Miura NH, Taniyama M, et al. (2003). "SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method.". BMC Med. Genet. 3: 6. doi:10.1186/1471-2350-3-6. PMC 117798. PMID 12147176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117798.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
Fujita Y, Ezura Y, Emi M, et al. (2004). "Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.". J. Hum. Genet. 49 (1): 24–8. doi:10.1007/s10038-003-0101-8. PMID 14661079.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.". Proteomics 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718.
Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.

ITIH4

See also

References

Further reading