ITGB3BP

Integrin beta 3 binding protein (beta3-endonexin)

Identifiers

ITGB3BP; CENP-R; CENPR; HSU37139; NRIF3; TAP20

External IDs

OMIM: 605494 MGI: 1914983 HomoloGene: 8617 GeneCards: ITGB3BP Gene

Gene Ontology
Molecular function	• signal transducer activity • protein C-terminus binding
Cellular component	• chromosome, centromeric region • membrane fraction • nucleus • nucleoplasm • nucleoplasm • chromosome • nucleolus • cytoplasm • cytosol • cytosol
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • nucleosome assembly • regulation of transcription, DNA-dependent • apoptosis • cell adhesion • signal transduction • induction of apoptosis by extracellular signals • CenH3-containing nucleosome assembly at centromere • nerve growth factor receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000142856

ENSMUSG00000028549

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
63.91 – 64.06 Mb

Chr 4:
99.43 – 99.6 Mb

PubMed search

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.^[1]^[2]^[3]

Interactions

ITGB3BP has been shown to interact with Retinoid X receptor gamma,^[4] Cyclin A2,^[5] NFKB1,^[6] Retinoid X receptor alpha,^[2] Thyroid hormone receptor alpha^[4]^[2] and CD61.^[7]^[1]

References

^ ^a ^b Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (Dec 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol 131 (3): 807–16. doi:10.1083/jcb.131.3.807. PMC 2120613. PMID 7593198. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120613.
^ ^a ^b ^c Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (Feb 2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell Biol 19 (10): 7191–202. PMC 84712. PMID 10490654. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84712.
^ "Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23421.
^ ^a ^b Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMC 100002. PMID 11713274. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100002.
^ Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (Jan. 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase". Biochem. Biophys. Res. Commun. (UNITED STATES) 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. ISSN 0006-291X. PMID 10673397.
^ Besta, Felicitas; Massberg Steffen, Brand Korbinian, Müller Elke, Page Sharon, Grüner Sabine, Lorenz Michael, Sadoul Karin, Kolanus Waldemar, Lengyel Ernst, Gawaz Meinrad (Oct. 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell. Sci. (England) 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. ISSN 0021-9533. PMID 12244126.
^ Fujimoto, Tetsuro-Takahiro; Katsutani Shinya, Shimomura Takeshi, Fujimura Kingo (Jan. 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. (United States) 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. ISSN 0049-3848. PMID 11864709.

Further reading

Kashiwagi H, Schwartz MA, Eigenthaler M, et al. (1997). "Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail.". J. Cell Biol. 137 (6): 1433–43. doi:10.1083/jcb.137.6.1433. PMC 2132534. PMID 9182673. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132534.
Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169340.
Ohtoshi A, Maeda T, Higashi H, et al. (2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase.". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID 10673397.
Li D, Wang F, Samuels HH (2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100002.
Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (2002). "Novel alternatively spliced form of beta(3)-endonexin.". Thromb. Res. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. PMID 11864709.
Besta F, Massberg S, Brand K, et al. (2003). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.". J. Cell. Sci. 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. PMID 12244126.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Li D, Das S, Yamada T, Samuels HH (2004). "The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.". Mol. Cell. Biol. 24 (9): 3838–48. doi:10.1128/MCB.24.9.3838-3848.2004. PMC 387764. PMID 15082778. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387764.
Talukder AH, Gururaj A, Mishra SK, et al. (2004). "Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.". Mol. Cell. Biol. 24 (15): 6581–91. doi:10.1128/MCB.24.15.6581-6591.2004. PMC 444867. PMID 15254226. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=444867.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
Okada M, Cheeseman IM, Hori T, et al. (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.