ITGB1BP3

Integrin beta 1 binding protein 3

Identifiers

ITGB1BP3; MGC126624; MIBP; NRK2

External IDs

OMIM: 608705 MGI: 1916814 HomoloGene: 113783 GeneCards: ITGB1BP3 Gene

Gene Ontology
Molecular function	• nucleotide binding • protein binding • ATP binding • transferase activity • metal ion binding • ribosylnicotinamide kinase activity
Cellular component	• intracellular
Biological process	• pyridine nucleotide biosynthetic process • negative regulation of myoblast differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000077009

ENSMUSG00000004939

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
3.93 – 3.94 Mb

Chr 10:
80.66 – 80.66 Mb

PubMed search

Nicotinamide riboside kinase 2 is an enzyme that in humans is encoded by the ITGB1BP3 gene.^[1]^[2]^[3]

Interactions

ITGB1BP3 has been shown to interact with ST7.^[4]

References

^ Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J Cell Biol 147 (7): 1391–8. doi:10.1083/jcb.147.7.1391. PMC 2174245. PMID 10613898. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174245.
^ Bieganowski P, Brenner C (May 2004). "Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans". Cell 117 (4): 495–502. doi:10.1016/S0092-8674(04)00416-7. PMID 15137942.
^ "Entrez Gene: ITGB1BP3 integrin beta 1 binding protein 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27231.
^ Battle, Michele A; Maher Veronica M, McCormick J Justin (Jun. 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li J, Rao H, Burkin D, et al. (2003). "The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition.". Dev. Biol. 261 (1): 209–19. doi:10.1016/S0012-1606(03)00304-X. PMID 12941630.
Battle MA, Maher VM, McCormick JJ (2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways.". Biochemistry 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.