IQGAP2
Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[1][2]
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[2]
Interactions
IQGAP2 has been shown to interact with CDC42[1] and RAC1.[1]
References
Further reading
- McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. doi:10.1074/jbc.271.36.21732. PMID 8702968.
- Yin H, Morioka H, Towle CA et al. (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.
- Wennerberg K, Ellerbroek SM, Liu RY et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
- Schmidt VA, Scudder L, Devoe CE et al. (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood 101 (8): 3021–8. doi:10.1182/blood-2002-09-2807. PMID 12515716.
- Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Bouwmeester T, Bauch A, Ruffner H et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376–87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
- Wang H, Huo R, Xu M et al. (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5–6): 319–25. doi:10.1080/10425170400009012. PMID 15621655.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.