INF2

Inverted formin, FH2 and WH2 domain containing

Identifiers

INF2; C14orf151; C14orf173; DKFZp762A0214; FLJ22056; FSGS5; MGC13251; pp9484

External IDs

OMIM: 610982 MGI: 1917685 HomoloGene: 82406 GeneCards: INF2 Gene

Gene Ontology
Molecular function	• actin binding • binding • Rho GTPase binding
Cellular component	• nucleus • cytoplasm • endoplasmic reticulum • perinuclear region of cytoplasm
Biological process	• cellular component organization • actin cytoskeleton organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000203485

ENSMUSG00000037679

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
105.16 – 105.19 Mb

Chr 12:
113.83 – 113.85 Mb

PubMed search

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene.^[1]^[2]

Clinical significance

It can be associated with Focal segmental glomerulosclerosis.^[3]

References

^ Chhabra ES, Higgs HN (Sep 2006). "INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization". J Biol Chem 281 (36): 26754–67. doi:10.1074/jbc.M604666200. PMID 16818491.
^ "Entrez Gene: C14orf173 chromosome 14 open reading frame 173". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64423.
^ Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. (Jan 2010). "Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis". Nature Genetics 42 (1): 72–6. doi:10.1038/ng.505. PMC 2980844. PMID 20023659. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2980844.

Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Bindschadler M, McGrath JL (2004). "Formin' new ideas about actin filament generation". Proc. Natl. Acad. Sci. U.S.A. 101 (41): 14685–6. doi:10.1073/pnas.0406317101. PMC 522045. PMID 15466701. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522045.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.