Interleukin-7 receptor
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[1] [2] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15. Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
Function
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation . Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[3]
Diseases
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia, [4], multiple sclerosis,[5] rheumatoid arthritis and juvenile idiopathic arthritis.[6]
See also
References
- ^ Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.". Science 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077.
- ^ *Kroemer RT, Richards WG (1997). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. doi:10.1093/protein/9.12.1135. PMID 9010926.
- ^ "Entrez Gene: IL7R interleukin 7 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3575.
- ^ Zenatti, Priscila P; Ribeiro, Daniel; Li, Wenqing; Zuurbier, Linda; Silva, Milene C; Paganin, Maddalena; Tritapoe, Julia; Hixon, Julie A et al. (2011). "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia". Nature Genetics 43 (10): 932–9. doi:10.1038/ng.924. ISSN 1061-4036. PMID 21892159.
- ^ Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL (September 2007). "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis". Nat. Genet. 39 (9): 1083–91. doi:10.1038/ng2103. PMID 17660817.
- ^ O'Doherty C, Alloza I, Rooney M, Vandenbroeck K (November 2009). "IL7RA polymorphisms and chronic inflammatory arthropathies". Tissue Antigens 74 (5): 429–31. doi:10.1111/j.1399-0039.2009.01342.x. PMID 19744146.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Chemokine receptor
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| TNF receptor |
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| JAK-STAT |
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| Ig superfamily |
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| IL-17 family |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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