| Interleukin 27 | |
|---|---|
| Identifiers | |
| Symbol | IL27 |
| Alt. symbols | IL30, p28 |
| Entrez | 246778 |
| HUGO | 19157 |
| OMIM | 608273 |
| RefSeq | NM_145659 |
| UniProt | Q6P676 |
| Other data | |
| Locus | Chr. 16 p11 |
| Epstein-Barr virus induced 3 | |
|---|---|
| Identifiers | |
| Symbol | EBI3 |
| Alt. symbols | IL-27B |
| Entrez | 10148 |
| HUGO | 3129 |
| OMIM | 605816 |
| RefSeq | NM_005755 |
| UniProt | Q14213 |
| Other data | |
| Locus | Chr. 19 p13 |
Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).[1] IL-27 is produced by antigen-presenting cells.[2] IL-27 plays an important function in regulating the activity of B and T lymphocytes.[3] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL27R and gp130.[4]
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