IKZF4

IKAROS family zinc finger 4 (Eos)
Identifiers
Symbols IKZF4; EOS; KIAA1782; ZNFN1A4
External IDs OMIM606239 MGI1343139 HomoloGene69103 GeneCards: IKZF4 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 64375 22781
Ensembl ENSG00000123411 ENSMUSG00000002578
UniProt Q9H2S9 n/a
RefSeq (mRNA) NM_022465 NM_011772.2
RefSeq (protein) NP_071910 NP_035902.2
Location (UCSC) Chr 12:
56.41 – 56.43 Mb
Chr 10:
128.07 – 128.08 Mb
PubMed search [1] [2]

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.[1][2]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM][2]

Interactions

IKZF4 has been shown to interact with CTBP1[3] and IKZF1.[1][4]

References

  1. ^ a b Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333. 
  2. ^ a b "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64375. 
  3. ^ Perdomo, José; Crossley Merlin (Dec. 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. (Germany) 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977. 
  4. ^ Honma, Y; Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A (Mar. 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. (NETHERLANDS) 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. 

Further reading