Glycoprotein IIb/IIIa

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Identifiers
Symbol ITGA2B
Alt. symbols GP2B
Entrez 3674
HUGO 6138
OMIM 607759
RefSeq NM_000419
UniProt P08514
Other data
Locus Chr. 17 q21.32
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Identifiers
Symbol ITGB3
Alt. symbols GP3A
Entrez 3690
HUGO 6156
OMIM 173470
RefSeq NM_000212
UniProt P05106
Other data
Locus Chr. 17 q21.32

In medicine, glycoprotein IIb/IIIa (gpIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and aids in platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.[1][2] Platelet activation by ADP (blocked by clopidogrel) leads to a conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban.

Contents

Pathology

Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia.[3]

Autoantibodies against IIb/IIIa can be produced in immune thrombocytopenic purpura.[4]

Medicine

Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.

See also

References

  1. ^ Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429. 
  2. ^ Shattil SJ (1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thromb. Haemost. 82 (2): 318–25. PMID 10605720. 
  3. ^ Bellucci S, Caen J (2002). "Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment". Blood Rev. 16 (3): 193–202. doi:10.1016/S0268-960X(02)00030-9. PMID 12163005. 
  4. ^ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470. http://linkinghub.elsevier.com/retrieve/pii/S0037-1963(07)00159-X. 

External links

Calcium-independent
Calcium-dependent
Classical
CDH1 · CDH2 · CDH3
Unconventional/ungrouped
T-cadherin · CDH4 · CDH5 · CDH6 · CDH8 · CDH11 · CDH12 · CDH15 · CDH16 · CDH17 · CDH9 · CDH10
Other
see also cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr
Alpha
A1 · A2 · A3 · A4 · A5 · A6 · A7 · A8 · A9 · A10 · A11 · AD · AE · AL · AM · AV · AX
Beta
B1 · B2 · B3 · B4 · B5 · B6 · B7 · B8
Dimers

Cytoadhesin receptor: Integrin alpha6beta4 · Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Fibrinogen receptor: Macrophage-1 antigen (CD11b+CD18)

Fibronectin receptor: Integrin alpha2beta1 · Integrin alpha4beta1 · Integrin alpha5beta1

Leukocyte-adhesion receptor: LFA-1 (CD11a+CD18) · Macrophage-1 antigen (CD11b+CD18) · Integrin alphaXbeta2 (CD11c+CD18)

Very late antigen receptor: Integrin alpha1beta1 · Integrin alpha2beta1 · Integrin alpha3beta1 · VLA-4 (CD49d+CD29)  · Alpha-5 beta-1 · Integrin alpha6beta1

Vitronectin receptor: Alpha-v beta-3 · Alpha-v beta-5
see also cell surface receptor deficiencies
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
Coagulation factors

vWF

platelet membrane glycoproteins: Ib (A, B, IX) · IIb/IIIa (IIb, IIIa) · VI
Coagulation inhibitors
Thrombolysis/fibrinolysis

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns