IGLC2

Immunoglobulin lambda constant 2 (Kern-Oz- marker)

Identifiers

IGLC2; IGLC; MGC20392; MGC45681

External IDs

Gene Ontology
Molecular function	• antigen binding
Cellular component	• extracellular region • extracellular region
Biological process	• complement activation • complement activation, classical pathway • innate immune response • regulation of immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

Chr 22:
23.25 – 23.25 Mb

n/a

PubMed search

[1]

n/a

Ig lambda chain C regions is a protein that in humans is encoded by the IGLC2 gene.^[1]

References

^ "Entrez Gene: IGLC2 immunoglobulin lambda constant 2 (Kern-Oz- marker)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3538.

Vasicek TJ, Leder P (1990). "Structure and expression of the human immunoglobulin lambda genes.". J. Exp. Med. 172 (2): 609–20. doi:10.1084/jem.172.2.609. PMC 2188323. PMID 2115572. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2188323.
Ely KR, Herron JN, Harker M, Edmundson AB (1990). "Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms.". J. Mol. Biol. 210 (3): 601–15. doi:10.1016/0022-2836(89)90135-6. PMID 2515285.
Dariavach P, Lefranc G, Lefranc MP (1988). "Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes.". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9074–8. doi:10.1073/pnas.84.24.9074. PMC 299694. PMID 3122211. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=299694.
Poljak RJ, Amzel LM, Chen BL, et al. (1975). "The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-angstrom resolution.". Proc. Natl. Acad. Sci. U.S.A. 71 (9): 3440–4. doi:10.1073/pnas.71.9.3440. PMC 433789. PMID 4215080. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=433789.
Fett JW, Deutsch HF (1974). "Primary structure of the Mcg lambda chain.". Biochemistry 13 (20): 4102–14. doi:10.1021/bi00717a007. PMID 4415202.
Chen BL, Poljak RJ (1974). "Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New).". Biochemistry 13 (6): 1295–302. doi:10.1021/bi00703a037. PMID 4814727.
Milstein C, Clegg JB, Jarvis JM (1969). "Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein.". Biochem. J. 110 (4): 631–52. PMC 1187434. PMID 4883841. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1187434.
Titani K, Wikler M, Shinoda T, Putnam FW (1970). "The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges.". J. Biol. Chem. 245 (8): 2171–6. PMID 4909564.
Ponstingl H, Hess M, Hilschmann N (1971). "[Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation]". Hoppe-Seyler's Z. Physiol. Chem. 352 (2): 247–66. PMID 5549568.
Hieter PA, Hollis GF, Korsmeyer SJ, et al. (1982). "Clustered arrangement of immunoglobulin lambda constant region genes in man.". Nature 294 (5841): 536–40. doi:10.1038/294536a0. PMID 6273747.
Kametani F, Takayasu T, Suzuki S, et al. (1983). "Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup.". J. Biochem. 93 (2): 421–9. PMID 6404900.
Stoppini M, Bellotti V, Negri A, et al. (1995). "Characterization of the two unique human anti-flavin monoclonal immunoglobulins.". Eur. J. Biochem. 228 (3): 886–93. doi:10.1111/j.1432-1033.1995.tb20336.x. PMID 7737190.
Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus.". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
van der Burg M, Barendregt BH, van Gastel-Mol EJ, et al. (2002). "Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus.". J. Immunol. 169 (1): 271–6. PMID 12077254.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

IGLC2

References

Further reading