IGHE

Immunoglobulin heavy constant epsilon

Identifiers

External IDs

Gene Ontology
Molecular function	• antigen binding
Biological process	• immune response

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

n/a

PubMed search

[1]

n/a

Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.^[1]

References

^ "Entrez Gene: IGHE immunoglobulin heavy constant epsilon". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3497.

Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (1991). "The B-cell antigen receptor of the five immunoglobulin classes.". Nature 352 (6338): 777–81. doi:10.1038/352777a0. PMID 1881434.
Padlan EA, Davies DR (1987). "A model of the Fc of immunoglobulin E.". Mol. Immunol. 23 (10): 1063–75. doi:10.1016/0161-5890(86)90005-2. PMID 3796618.
Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.". EMBO J. 1 (5): 655–60. PMC 553102. PMID 6234164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553102.
Max EE, Battey J, Ney R, et al. (1982). "Duplication and deletion in the human immunoglobulin epsilon genes.". Cell 29 (2): 691–9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268.
Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene.". DNA 1 (1): 11–8. PMID 6299662.
Seno M, Kurokawa T, Ono Y, et al. (1983). "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA.". Nucleic Acids Res. 11 (3): 719–26. doi:10.1093/nar/11.3.719. PMC 325748. PMID 6300763. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=325748.
Ueda S, Nakai S, Nishida Y, et al. (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns.". EMBO J. 1 (12): 1539–44. PMC 553248. PMID 6327276. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553248.
Hisajima H, Nishida Y, Nakai S, et al. (1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin.". Proc. Natl. Acad. Sci. U.S.A. 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=393960.
Flanagan JG, Lefranc MP, Rabbitts TH (1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences.". Cell 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489.
Ellison J, Hood L (1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.". Proc. Natl. Acad. Sci. U.S.A. 79 (6): 1984–8. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=346106.
Kenten JH, Molgaard HV, Houghton M, et al. (1983). "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6661–5. doi:10.1073/pnas.79.21.6661. PMC 347188. PMID 6815656. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=347188.
Valenta R, Natter S, Seiberler S, et al. (1999). "Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients.". J. Invest. Dermatol. 111 (6): 1178–83. doi:10.1046/j.1523-1747.1998.00413.x. PMID 9856836.
Anderson GG, Leaves NI, Bhattacharyya S, et al. (2002). "Positive association to IgE levels and a physical map of the 13q14 atopy locus.". Eur. J. Hum. Genet. 10 (4): 266–70. doi:10.1038/sj.ejhg.5200801. PMID 12032735.
Cocco RR, Järvinen KM, Sampson HA, Beyer K (2003). "Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen.". J. Allergy Clin. Immunol. 112 (2): 433–7. doi:10.1067/mai.2003.1617. PMID 12897753.
Hajoui O, Janani R, Tulic M, et al. (2004). "Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production.". J. Allergy Clin. Immunol. 114 (3): 657–63. doi:10.1016/j.jaci.2004.05.034. PMID 15356573.
Takhar P, Smurthwaite L, Coker HA, et al. (2005). "Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis.". J. Immunol. 174 (8): 5024–32. PMID 15814733.
Batra J, Rajpoot R, Ahluwalia J, et al. (2007). "A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels.". J. Med. Genet. 44 (6): 397–403. doi:10.1136/jmg.2006.046607. PMC 2740889. PMID 17220216. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2740889.

IGHE

References

Further reading