IGHD

Immunoglobulin heavy constant delta

Identifiers

IGHD; FLJ00382; FLJ46727; MGC29633

External IDs

Gene Ontology
Molecular function	• antigen binding
Cellular component	• extracellular region • plasma membrane • integral to membrane
Biological process	• immune response

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

n/a

PubMed search

[1]

n/a

Ig delta chain C region is a protein that in humans is encoded by the IGHD gene.^[1]^[2]

References

^ White MB, Shen AL, Word CJ, Tucker PW, Blattner FR (May 1985). "Human immunoglobulin D: genomic sequence of the delta heavy chain". Science 228 (4700): 733–7. doi:10.1126/science.3922054. PMID 3922054.
^ "Entrez Gene: IGHD immunoglobulin heavy constant delta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3495.

Shin SU, Wei CF, Amin AR, et al. (1992). "Structural and functional properties of mouse-human chimeric IgD.". Hum. Antibodies Hybridomas 3 (2): 65–74. PMID 1633267.
Roes J, Rajewsky K (1992). "Cell autonomous expression of IgD is not essential for the maturation of conventional B cells.". Int. Immunol. 3 (12): 1367–71. doi:10.1093/intimm/3.12.1367. PMID 1838007.
Shinoda T, Takahashi N, Takayasu T, et al. (1981). "Complete amino acid sequence of the Fc region of a human delta chain". Proc. Natl. Acad. Sci. U.S.A. 78 (2): 785–9. doi:10.1073/pnas.78.2.785. PMC 319887. PMID 6785754. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=319887.
Lin LC, Putnam FW (1981). "Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function". Proc. Natl. Acad. Sci. U.S.A. 78 (1): 504–8. doi:10.1073/pnas.78.1.504. PMC 319082. PMID 6787589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=319082.
Putnam FW, Takahashi N, Tetaert D, et al. (1982). "Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD". Proc. Natl. Acad. Sci. U.S.A. 78 (10): 6168–72. doi:10.1073/pnas.78.10.6168. PMC 348999. PMID 6947220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=348999.
Takayasu T, Takahashi N, Shinoda T (1981). "Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D". Biochem. Biophys. Res. Commun. 97 (2): 635–41. doi:10.1016/0006-291X(80)90311-3. PMID 7008791.
Takayasu T, Suzuki S, Kametani F, et al. (1982). "Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D". Biochem. Biophys. Res. Commun. 105 (3): 1066–71. doi:10.1016/0006-291X(82)91078-6. PMID 7092891.
Roes J, Rajewsky K (1993). "Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells". J. Exp. Med. 177 (1): 45–55. doi:10.1084/jem.177.1.45. PMC 2190865. PMID 8418208. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190865.
Scott IC, Halila R, Jenkins JM, et al. (1996). "Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)". Gene 174 (1): 135–43. doi:10.1016/0378-1119(96)00510-0. PMID 8863740.
Zupo S, Cutrona G, Mangiola M, Ferrarini M (2002). "Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia". Blood 99 (6): 2277–8. doi:10.1182/blood-2001-11-0126. PMID 11902141.
Gala FA, Morrison SL (2002). "The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1". J. Biol. Chem. 277 (32): 29005–11. doi:10.1074/jbc.M203258200. PMID 12023968.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Schamel WW, Kuppig S, Becker B, et al. (2003). "A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9861–6. doi:10.1073/pnas.1633363100. PMC 187866. PMID 12886015. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187866.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.
Lee CE, Gaëta B, Malming HR, et al. (2006). "Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire". Immunogenetics 57 (12): 917–25. doi:10.1007/s00251-005-0062-5. PMID 16402215.
Lee CE, Jackson KJ, Sewell WA, Collins AM (2007). "Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia". Leuk. Res. 31 (9): 1247–52. doi:10.1016/j.leukres.2006.10.013. PMID 17169423.
Samuelsson M, Hallström T, Forsgren A, Riesbeck K (2007). "Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b". J. Immunol. 178 (10): 6316–9. PMID 17475860.

IGHD

References

Further reading